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Substance Name: Talniflumate [USAN:INN]
RN: 66898-62-2
UNII: JFK78S0U9S
InChIKey: ANMLJLFWUCQGKZ-UHFFFAOYSA-N

Note

  • An anti-inflammatory molecule for the treatment of cystic fibrosis, chronic obstructive pulmonary disease and asthma.

Molecular Formula

  • C21-H13-F3-N2-O4

Molecular Weight

  • 414.338
 

Classification Codes

  • Analgesic
  • Anti-Inflammatory
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Talniflumate
  • Talniflumate [USAN:INN]

Synonyms

  • 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester
  • 3-Ftalidilico del acido 2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilico
  • 3-Ftalidilico del acido 2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilico [Spanish]
  • 3-Phthalidyl ester of 2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid
  • 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
  • BA 7602-06
  • BRN 0503261
  • Lomucin
  • Phthalidyl 2-(3-trifluoromethylanilino)nicotinate
  • Phthalidyl 2-(alpha,alpha,alpha,-trifluoro-m-toluidino)nicotinate
  • Phthalidyl 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate
  • Somalgen
  • Talniflumate
  • Talniflumato
  • Talniflumato [INN-Spanish]
  • Talniflumatum
  • Talniflumatum [INN-Latin]
  • UNII-JFK78S0U9S

Systematic Names

  • 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
  • Nicotinic acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-, phthalidyl ester

Registry Numbers

CAS Registry Number

  • 66898-62-2

FDA UNII

  • JFK78S0U9S

System Generated Number

  • 0066898622

Structure Descriptors

InChI

1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)

InChIKey

ANMLJLFWUCQGKZ-UHFFFAOYSA-N

Smiles

c12[C@@H](OC(c1cccc2)=O)OC(c1c(Nc2cc(ccc2)C(F)(F)F)nccc1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 4gm/kg (4000mg/kg)   Drugs of the Future. Vol. 4, Pg. 448, 1979.
rat LD subcutaneous > 1gm/kg (1000mg/kg)   Drugs of the Future. Vol. 4, Pg. 448, 1979.
rat LD50 oral 12gm/kg (12000mg/kg)   Farmaco, Edizione Scientifica. Vol. 36, Pg. 372, 1981.