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Substance Name: Choline chloride [INN]
RN: 67-48-1
UNII: 45I14D8O27
InChIKey: SGMZJAMFUVOLNK-UHFFFAOYSA-M

Note

  • A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Molecular Formula

  • C5-H14-N-O.Cl

Molecular Weight

  • 139.6246
 

Classification Code

  • Mutation Data

Names and Synonyms

Name of Substance

  • Choline chloride
  • Choline chloride [INN]

Synonyms

  • (2-Hydroxyethyl)trimethylammonium chloride
  • (beta-Hydroxyethyl)trimethylammonium chloride
  • 2-Hydroxy-N,N,N,-trimethylethanaminium chloride
  • 2-Hydroxy-N,N,N-trimethylethanaminium chloride
  • AI3-18302
  • Ammonium, (2-hydroxyethyl)trimethyl-, chloride
  • Bilineurin chloride
  • Biocolina
  • Biocoline
  • CCRIS 3716
  • Chloride de choline
  • Chloride de choline [French]
  • Chlorure de choline
  • Chlorure de choline [INN-French]
  • CHOLINE (CL)
  • Choline chlorhydrate
  • Choline chloride
  • Choline hydrochloride
  • Cholini chloridum
  • Cholini chloridum [INN-Latin]
  • Cholinium chloride
  • Cloruro de colina
  • Cloruro de colina [INN-Spanish]
  • Colina cloruro
  • Colina cloruro [DCIT]
  • EC 200-655-4
  • EINECS 200-655-4
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
  • Hepacholine
  • Hormocline
  • HSDB 984
  • Lipotril
  • Luridin chloride
  • Neocolina
  • NSC 402838
  • Paresan
  • Trimethyl(2-hydroxyethyl)ammonium chloride
  • UNII-45I14D8O27

Systematic Names

  • (2-Hydroxyethyl)trimethylammonium chloride
  • Choline chloride
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)

Superlist Names

  • Choline chloride
  • Choline chloride solutions
  • Choline, chloride

Registry Numbers

CAS Registry Number

  • 67-48-1

FDA UNII

  • 45I14D8O27

Related Registry Number

  • 62-49-7 (Parent)

System Generated Number

  • 0000067481

Molecular Formulas

Molecular Formula

  • C5-H14-N-O.Cl

Molecular Formula Fragments

  • C5-H14-N-O
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChIKey

SGMZJAMFUVOLNK-UHFFFAOYSA-M

Smiles

C[N+](C)(C)CCO.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 25mg/kg (25mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo intravenous 5mg/kg (5mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog LDLo unreported 1500mg/kg (1500mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse LD50 intravenous 53mg/kg (53mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse LD50 oral 3900mg/kg (3900mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse LDLo subcutaneous 735mg/kg (735mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915.
rabbit LDLo intraperitoneal 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE
Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit LDLo intravenous 1100ug/kg (1.1mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit LDLo rectal 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit LDLo subcutaneous 1gm/kg (1000mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rat LD50 intraperitoneal 450mg/kg (450mg/kg)   Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986.
rat LD50 oral 3400mg/kg (3400mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 305 dec deg C   EXP
log P (octanol-water) -5.160 (none)   EST
Atmospheric OH Rate Constant 1.86E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.