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Substance Name: Choline chloride [INN]
RN: 67-48-1
UNII: 45I14D8O27
InChIKey: SGMZJAMFUVOLNK-UHFFFAOYSA-M
Note
- A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Molecular Formula
- C5-H14-N-O.Cl
Molecular Weight
- 139.6246
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- Registry Numbers
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- Physical Properties
Classification Code
- Mutation Data
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Names and Synonyms
Name of Substance
- Choline chloride
- Choline chloride [INN]
Synonyms
- (2-Hydroxyethyl)trimethylammonium chloride
- (beta-Hydroxyethyl)trimethylammonium chloride
- 2-Hydroxy-N,N,N,-trimethylethanaminium chloride
- 2-Hydroxy-N,N,N-trimethylethanaminium chloride
- AI3-18302
- Ammonium, (2-hydroxyethyl)trimethyl-, chloride
- Bilineurin chloride
- Biocolina
- Biocoline
- CCRIS 3716
- Chloride de choline
- Chloride de choline [French]
- Chlorure de choline
- Chlorure de choline [INN-French]
- CHOLINE (CL)
- Choline chlorhydrate
- Choline chloride
- Choline hydrochloride
- Cholini chloridum
- Cholini chloridum [INN-Latin]
- Cholinium chloride
- Cloruro de colina
- Cloruro de colina [INN-Spanish]
- Colina cloruro
- Colina cloruro [DCIT]
- EC 200-655-4
- EINECS 200-655-4
- Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
- Hepacholine
- Hormocline
- HSDB 984
- Lipotril
- Luridin chloride
- Neocolina
- NSC 402838
- Paresan
- Trimethyl(2-hydroxyethyl)ammonium chloride
- UNII-45I14D8O27
Systematic Names
- (2-Hydroxyethyl)trimethylammonium chloride
- Choline chloride
- Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
- Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
Superlist Names
- Choline chloride
- Choline chloride solutions
- Choline, chloride
Registry Numbers
CAS Registry Number
- 67-48-1
FDA UNII
- 45I14D8O27
Other Registry Numbers
- 1643859-93-1
- 2028303-08-2
Related Registry Number
- 62-49-7 (Parent)
System Generated Number
- 0000067481
Molecular Formulas
Molecular Formula
- C5-H14-N-O.Cl
Molecular Formula Fragments
- C5-H14-N-O
- Cl
- COMPONENT
Structure Descriptors
InChI
1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1InChIKey
SGMZJAMFUVOLNK-UHFFFAOYSA-MSmiles
C[N+](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 25mg/kg (25mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
dog | LDLo | intravenous | 5mg/kg (5mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
frog | LDLo | unreported | 1500mg/kg (1500mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942. | |
mouse | LD50 | intraperitoneal | 320mg/kg (320mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942. | |
mouse | LD50 | intravenous | 53mg/kg (53mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983. |
mouse | LD50 | oral | 3900mg/kg (3900mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983. |
mouse | LDLo | subcutaneous | 735mg/kg (735mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915. | |
rabbit | LDLo | intraperitoneal | 500mg/kg (500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE | Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928. |
rabbit | LDLo | intravenous | 1100ug/kg (1.1mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942. |
rabbit | LDLo | rectal | 1gm/kg (1000mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942. |
rabbit | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942. | |
rat | LD50 | intraperitoneal | 450mg/kg (450mg/kg) | Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986. | |
rat | LD50 | oral | 3400mg/kg (3400mg/kg) | BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 305 dec | deg C | EXP | |
log P (octanol-water) | -5.160 | (none) | EST | |
Atmospheric OH Rate Constant | 1.86E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.