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Substance Name: Isopropyl alcohol [USP]
RN: 67-63-0
UNII: ND2M416302
InChIKey: KFZMGEQAYNKOFK-UHFFFAOYSA-N

Note

  • An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

Molecular Formula

  • C3-H8-O

Molecular Weight

  • 60.0952
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Anti-Infective, Topical
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Solvent)
  • Reproductive Effect
  • Skin / Eye Irritant
  • Slimicide
  • Solvents
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 3
  • TWA (200 ppm); STEL (400 ppm); Not classifiable as a human carcinogen
  • TWA 400 ppm (980 mg/m3)

Names and Synonyms

Name of Substance

  • 2-Propanol
  • Isopropanol
  • Isopropyl alcohol [USP]

MeSH Heading

  • 2-Propanol

Synonyms

  • 1-Methylethanol
  • 1-Methylethyl alcohol
  • 2-Hydroxypropane
  • 2-Propanol
  • 2-Propyl alcohol
  • 4-01-00-01461 (Beilstein Handbook Reference)
  • AI3-01636
  • Alcojel
  • Alcolo
  • Alcool isopropilico
  • Alcool isopropilico [Italian]
  • Alcool isopropylique
  • Alcool isopropylique [French]
  • Alcosolve
  • Alcosolve 2
  • Alkolave
  • Arquad DMCB
  • Avantin
  • Avantine
  • BRN 0635639
  • Caswell No. 507
  • CCRIS 2308
  • Combi-schutz
  • Dimethylcarbinol
  • EC 200-661-7
  • EINECS 200-661-7
  • EPA Pesticide Chemical Code 047601
  • FEMA No. 2929
  • FEMA Number 2929
  • Hartosol
  • HSDB 116
  • i-Propanol
  • i-Propanol [German]
  • i-Propyl alcohol
  • i-Propylalkohol
  • i-Propylalkohol [German]
  • Imsol A
  • Iso-propylalkohol
  • Iso-propylalkohol [German]
  • Isohol
  • Isopropanol
  • Isopropyl alcohol
  • Isopropyl alcohol, rubbing
  • Lavacol
  • Lutosol
  • n-Propan-2-ol
  • NSC 135801
  • Petrohol
  • Propol
  • sec-Propyl alcohol
  • Spectrar
  • Sterisol hand disinfectant
  • Takineocol
  • UNII-ND2M416302
  • Visco 1152

Systematic Names

  • 2-Propanol
  • Isopropyl alcohol
  • Propan-2-ol

Superlist Names

  • 2-Propanol
  • Iso-propyl alcohol
  • Isopropanol
  • Isopropanol or isopropyl alcohol
  • Isopropanol or isopropyl alcohol [UN1219] [Flammable liquid]
  • Isopropyl alcohol
  • Isopropyl alcohol (manufacture strong-acid process)
  • Isopropyl alcohol (manufacturing-strong acid process only)
  • Isopropyl alcohol (only persons who manufacture by the strong acid process are subject, supplier notification not required)
  • UN1219

Mixture Name

  • Hibistat

Registry Numbers

CAS Registry Number

  • 67-63-0

FDA UNII

  • ND2M416302

Other Registry Number

  • 8013-70-5

System Generated Number

  • 0000067630

Structure Descriptors

InChI

1S/C3H8O/c1-3(2)4/h3-4H,1-2H3

InChIKey

KFZMGEQAYNKOFK-UHFFFAOYSA-N

Smiles

C(C)(C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1963mg/kg (1963mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 172, 1955.
cat LDLo oral 6mL/kg (6mL/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 26, Pg. 285, 1921.
dog LDLo intravenous 1024mg/kg (1024mg/kg)   Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 561, 1944.
dog LDLo oral 1537mg/kg (1537mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 561, 1944.
frog LDLo parenteral 20gm/kg (20000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935.
guinea pig LD50 intraperitoneal 2560mg/kg (2560mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
hamster LD50 intraperitoneal 3444mg/kg (3444mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
human LDLo oral 3570mg/kg (3570mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: COMA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 339, 1969.
human LDLo unreported 2mL/kg (2mL/kg)   Japanese Journal of Toxicology. Vol. 12, Pg. 341, 1999.
human TDLo oral 223mg/kg (223mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: PULSE RATE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Laboratory and Clinical Medicine. Vol. 12, Pg. 326, 1927.
infant TDLo oral 13gm/kg (13000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: IRRITABILITY

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Emergency Medicine. Vol. 10, Pg. 542, 1992.
infant TDLo unreported 1375mg/kg (1375mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Pediatric Emergency Care. Vol. 9, Pg. 146, 1993.
mammal (species unspecified) LDLo subcutaneous 6gm/kg (6000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Archiv fuer Toxikologie. Vol. 16, Pg. 84, 1956.
man LDLo oral 5272mg/kg (5272mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Clinical Pathology. Vol. 38, Pg. 144, 1962.
man LDLo unreported 2770mg/kg (2770mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 14432mg/kg (14432mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
New England Journal of Medicine. Vol. 277, Pg. 699, 1967.
mouse LCLo inhalation 12800ppm/3H (12800ppm)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LD50 intraperitoneal 4477mg/kg (4477mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
mouse LD50 intravenous 1509mg/kg (1509mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
mouse LD50 oral 3600mg/kg (3600mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978.
mouse LDLo subcutaneous 6gm/kg (6000mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 172, 1955.
rabbit LD50 intraperitoneal 667mg/kg (667mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
rabbit LD50 intravenous 1184mg/kg (1184mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
rabbit LD50 oral 6410mg/kg (6410mg/kg)   FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 114, 1970.
rabbit LD50 skin 12800mg/kg (12800mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974.
rat LC50 inhalation 16000ppm/8H (16000ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974.
rat LD50 intraperitoneal 2735mg/kg (2735mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
rat LD50 intravenous 1088mg/kg (1088mg/kg)   EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
rat LD50 oral 5045mg/kg (5045mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -8.95E+01 deg C   EXP
Boiling Point 82.3 deg C   EXP
pKa Dissociation Constant 17.1 (none)   EXP
log P (octanol-water) 0.05 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 45.4 mm Hg 25 EXP
Henry's Law Constant 8.10E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 5.07E-12 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.