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Substance Name: Acetone [NF]
RN: 67-64-1
UNII: 1364PS73AF
InChIKey: CSCPPACGZOOCGX-UHFFFAOYSA-N

Note

  • A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.

Molecular Formula

  • C3-H6-O

Molecular Weight

  • 58.0794
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Solvent)
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 184
  • 2011 CERCLA Priority List, Rank: 186
  • Reportable Quantity (RQ) = 5000 lb
  • TWA 1000 ppm (2400 mg/m3)
  • TWA:500 ppm; STEL:750 ppm; Not classifiable as a human carcinogen, BEI

Names and Synonyms

Name of Substance

  • 2-Propanone
  • Acetone
  • Acetone [NF]
  • Dimethyl ketone

MeSH Heading

  • Acetone

Synonyms

  • 2-Propanone
  • Aceton
  • Aceton [German, Dutch, Polish]
  • Acetone
  • Acetone (natural)
  • AI3-01238
  • beta-Ketopropane
  • Caswell No. 004
  • CCRIS 5953
  • Chevron acetone
  • Dimethyl ketone
  • Dimethylformaldehyde
  • Dimethylketal
  • EC 200-662-2
  • EINECS 200-662-2
  • EPA Pesticide Chemical Code 004101
  • FEMA No. 3326
  • HSDB 41
  • Ketone propane
  • Ketone, dimethyl
  • Methyl ketone
  • NSC 135802
  • Propanone
  • Pyroacetic acid
  • Pyroacetic ether
  • RCRA waste number U002
  • UNII-1364PS73AF

Systematic Names

  • 2-Propanone
  • Acetone

Superlist Names

  • 2-Propanone
  • Acetone
  • Acetone [UN1090] [Flammable liquid]
  • Methyl ketone
  • RCRA waste no. U002
  • UN1090

Registry Numbers

CAS Registry Number

  • 67-64-1

FDA UNII

  • 1364PS73AF

System Generated Number

  • 0000067641

Structure Descriptors

InChI

1S/C3H6O/c1-3(2)4/h1-2H3

InChIKey

CSCPPACGZOOCGX-UHFFFAOYSA-N

Smiles

C(C)(C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intraperitoneal 8gm/kg (8000mg/kg) GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION

BEHAVIORAL: COMA		 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884.
dog LDLo oral 8gm/kg (8000mg/kg) MUSCULOSKELETAL: JOINTS

BEHAVIORAL: COMA

BEHAVIORAL: ATAXIA		 Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884.
dog LDLo subcutaneous 5gm/kg (5000mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884.
guinea pig LD50 skin > 9400uL/kg (9.4mL/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965.
guinea pig LDLo subcutaneous 5gm/kg (5000mg/kg)   Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
human TCLo inhalation 500ppm (500ppm) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION		 Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.
man LDLo unreported 1159mg/kg (1159mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TCLo inhalation 440ug/m3/6M (0.44mg/m3) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(8), Pg. 42, 1977.
man TCLo inhalation 10mg/m3/6H (10mg/m3)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(8), Pg. 42, 1977.
man TCLo inhalation 12000ppm/4H (12000ppm) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: NAUSEA OR VOMITING		 Annals of Occupational Hygiene. Vol. 16, Pg. 73, 1973.
man TDLo oral 2857mg/kg (2857mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BEHAVIORAL: COMA		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 64, 1969.
man TDLo oral 2857mg/kg (2857mg/kg) BEHAVIORAL: COMA Diabetes. Vol. 15, Pg. 810, 1966.
mouse LC50 inhalation 44gm/m3/4H (44000mg/m3)   Current Toxicology. Vol. 1, Pg. 47, 1993.
mouse LD50 intraperitoneal 1297mg/kg (1297mg/kg)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961.
mouse LD50 oral 3gm/kg (3000mg/kg)   Pharmaceutical Chemistry Journal Vol. 14, Pg. 162, 1980.
mouse LDLo intravenous 4gm/kg (4000mg/kg)   FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 86, 1970.
rabbit LD50 oral 5340mg/kg (5340mg/kg)   FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 86, 1970.
rabbit LDLo intravenous 1576mg/kg (1576mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928.
rabbit LDLo skin 20mL/kg (20mL/kg)   Union Carbide Data Sheet. Vol. 5/7/1970,
rat LC50 inhalation 50100mg/m3/8H (50100mg/m3)   American Industrial Hygiene Association Journal. Vol. 20, Pg. 364, 1959.
rat LD50 intravenous 5500mg/kg (5500mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 1, 1974.
rat LD50 oral 5800mg/kg (5800mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR		 Journal of Toxicology and Environmental Health. Vol. 15, Pg. 609, 1985.
rat LDLo intraperitoneal 500mg/kg (500mg/kg) KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: GENERAL ANESTHETIC		 Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -9.48E+01 deg C   EXP
Boiling Point 56 deg C   EXP
pKa Dissociation Constant 20 (none)   EXP
log P (octanol-water) -0.24 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 232 mm Hg 25 EXP
Henry's Law Constant 3.97E-05 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 2.19E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.