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Substance Name: Acetone [NF]
RN: 67-64-1
UNII: 1364PS73AF
InChIKey: CSCPPACGZOOCGX-UHFFFAOYSA-N
Note
- A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
Molecular Formula
- C3-H6-O
Molecular Weight
- 58.0794
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Human Data
- Mutation Data
- Pharmaceutic Aid (Solvent)
- Reproductive Effect
- Skin / Eye Irritant
- Solvents
- Tumor Data
Superlist Classification Codes
- 2007 CERCLA Priority List, Rank: 184
- 2011 CERCLA Priority List, Rank: 186
- Reportable Quantity (RQ) = 5000 lb
- TWA 1000 ppm (2400 mg/m3)
- TWA:500 ppm; STEL:750 ppm; Not classifiable as a human carcinogen, BEI
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Names and Synonyms
Name of Substance
- 2-Propanone
- Acetone
- Acetone [NF]
- Dimethyl ketone
MeSH Heading
- Acetone
Synonyms
- 2-Propanone
- Aceton
- Aceton [German, Dutch, Polish]
- Acetone
- Acetone (natural)
- AI3-01238
- beta-Ketopropane
- Caswell No. 004
- CCRIS 5953
- Chevron acetone
- Dimethyl ketone
- Dimethylformaldehyde
- Dimethylketal
- EC 200-662-2
- EINECS 200-662-2
- EPA Pesticide Chemical Code 004101
- FEMA No. 3326
- HSDB 41
- Ketone propane
- Ketone, dimethyl
- Methyl ketone
- NSC 135802
- Propanone
- Pyroacetic acid
- Pyroacetic ether
- RCRA waste number U002
- UNII-1364PS73AF
Systematic Names
- 2-Propanone
- Acetone
Superlist Names
- 2-Propanone
- Acetone
- Acetone [UN1090] [Flammable liquid]
- Methyl ketone
- RCRA waste no. U002
- UN1090
Registry Numbers
CAS Registry Number
- 67-64-1
FDA UNII
- 1364PS73AF
System Generated Number
- 0000067641
Structure Descriptors
InChI
InChI=1S/C3H6O/c1-3(2)4/h1-2H3InChIKey
CSCPPACGZOOCGX-UHFFFAOYSA-NSmiles
CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intraperitoneal | 8gm/kg (8000mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884. |
dog | LDLo | oral | 8gm/kg (8000mg/kg) | MUSCULOSKELETAL: JOINTS BEHAVIORAL: COMA BEHAVIORAL: ATAXIA | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884. |
dog | LDLo | subcutaneous | 5gm/kg (5000mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 18, Pg. 218, 1884. | |
guinea pig | LD50 | skin | > 9400uL/kg (9.4mL/kg) | Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965. | |
guinea pig | LDLo | subcutaneous | 5gm/kg (5000mg/kg) | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. | |
human | TCLo | inhalation | 500ppm (500ppm) | SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943. |
man | LDLo | unreported | 1159mg/kg (1159mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TCLo | inhalation | 440ug/m3/6M (0.44mg/m3) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(8), Pg. 42, 1977. |
man | TCLo | inhalation | 10mg/m3/6H (10mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(8), Pg. 42, 1977. | |
man | TCLo | inhalation | 12000ppm/4H (12000ppm) | BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING | Annals of Occupational Hygiene. Vol. 16, Pg. 73, 1973. |
man | TDLo | oral | 2857mg/kg (2857mg/kg) | BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: OTHER CHANGES | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 64, 1969. |
man | TDLo | oral | 2857mg/kg (2857mg/kg) | Diabetes. Vol. 15, Pg. 810, 1966. | |
man | TDLo | oral | 2857mg/kg (2857mg/kg) | BEHAVIORAL: COMA | Diabetes. Vol. 15, Pg. 810, 1966. |
mouse | LC50 | inhalation | 44gm/m3/4H (44000mg/m3) | Current Toxicology. Vol. 1, Pg. 47, 1993. | |
mouse | LD50 | intraperitoneal | 1297mg/kg (1297mg/kg) | Shell Chemical Company. Unpublished Report. Vol. -, Pg. 1, 1961. | |
mouse | LD50 | oral | 3gm/kg (3000mg/kg) | Pharmaceutical Chemistry Journal Vol. 14, Pg. 162, 1980. | |
mouse | LDLo | intravenous | 4gm/kg (4000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 86, 1970. | |
rabbit | LD50 | oral | 5340mg/kg (5340mg/kg) | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 86, 1970. | |
rabbit | LDLo | intravenous | 1576mg/kg (1576mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacology and Experimental Therapeutics. Vol. 33, Pg. 175, 1928. |
rabbit | LDLo | skin | 20mL/kg (20mL/kg) | Union Carbide Data Sheet. Vol. 5/7/1970, | |
rat | LC50 | inhalation | 50100mg/m3/8H (50100mg/m3) | American Industrial Hygiene Association Journal. Vol. 20, Pg. 364, 1959. | |
rat | LD50 | intravenous | 5500mg/kg (5500mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 1, 1974. | |
rat | LD50 | oral | 5800mg/kg (5800mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR | Journal of Toxicology and Environmental Health. Vol. 15, Pg. 609, 1985. |
rat | LDLo | intraperitoneal | 500mg/kg (500mg/kg) | KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: MUSCLE WEAKNESS | Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -9.48E+01 | deg C | EXP | |
Boiling Point | 56 | deg C | EXP | |
pKa Dissociation Constant | 20 | (none) | EXP | |
log P (octanol-water) | -0.24 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | 25 | EXP |
Vapor Pressure | 232 | mm Hg | 25 | EXP |
Henry's Law Constant | 3.97E-05 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 2.19E-13 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.