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Substance Name: Chloroform [NF]
RN: 67-66-3
UNII: 7V31YC746X
InChIKey: HEDRZPFGACZZDS-UHFFFAOYSA-N

Note

  • A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.

Molecular Formula

  • C-H-Cl3

Molecular Weight

  • 119.378
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 11
  • 2011 CERCLA Priority List, Rank: 11
  • Ceiling 50 ppm (240 mg/m3)
  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 10 lb
  • Threshold Planning Quantity (TPQ) = 10000 lb
  • TWA (10 ppm); Confirmed animal carcinogen with unknown relevance to humans

Names and Synonyms

Name of Substance

  • Chloroform
  • Chloroform [NF]

MeSH Heading

  • Chloroform

Synonyms

  • 1,1,1-Trichloromethane
  • 4-01-00-00042 (Beilstein Handbook Reference)
  • AI3-24207
  • BRN 1731042
  • Caswell No. 192
  • CCRIS 137
  • Chloroform
  • Chloroforme
  • Chloroforme [French]
  • Cloroformio
  • Cloroformio [Italian]
  • EC 200-663-8
  • EINECS 200-663-8
  • EPA Pesticide Chemical Code 020701
  • Formyl trichloride
  • Freon 20
  • HSDB 56
  • Methane trichloride
  • Methane, trichloro-
  • Methenyl chloride
  • Methenyl trichloride
  • Methyl trichloride
  • NCI-C02686
  • NSC 77361
  • R 20 (Refrigerant)
  • RCRA waste number U044
  • Trichloormethaan
  • Trichloormethaan [Dutch]
  • Trichlormethan
  • Trichlormethan [Czech]
  • Trichloromethane
  • Triclorometano
  • Triclorometano [Italian]
  • UNII-7V31YC746X

Systematic Names

  • Chloroform
  • Methane, trichloro-

Superlist Names

  • Chloroform
  • Chloroform [UN1888] [Poison]
  • Methane, trichloro-
  • RCRA waste no. U044
  • Trichloromethane
  • UN1888

Registry Numbers

CAS Registry Number

  • 67-66-3

FDA UNII

  • 7V31YC746X

Other Registry Number

  • 8013-54-5

System Generated Number

  • 0000067663

Structure Descriptors

InChI

1S/CHCl3/c2-1(3)4/h1H

InChIKey

HEDRZPFGACZZDS-UHFFFAOYSA-N

Smiles

C(Cl)(Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 35gm/m3/4H (35000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
dog LCLo inhalation 100gm/m3 (100000mg/m3)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 230, 1966.
dog LD50 intraperitoneal 1gm/kg (1000mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
dog LDLo intravenous 75mg/kg (75mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
dog LDLo oral 1gm/kg (1000mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
frog LCLo inhalation 6gm/m3 (6000mg/m3)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 97, Pg. 86, 1923.
guinea pig LCLo inhalation 20000ppm/2H (20000ppm)   Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.
guinea pig LD50 oral 820mg/kg (820mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(3), Pg. 10, 1983.
human LCLo inhalation 25000ppm/5M (25000ppm)   Tabulae Biologicae. Vol. 3, Pg. 231, 1933.
human TCLo inhalation 10mg/m3/1Y (10mg/m3) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING
Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 24, Pg. 127, 1967.
human TCLo inhalation 5000mg/m3/7M (5000mg/m3) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
mammal (species unspecified) LCLo inhalation 25000ppm/5M (25000ppm)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928.
man LDLo oral 2514mg/kg (2514mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: OTHER CHANGES
American Journal of Emergency Medicine. Vol. 6, Pg. 507, 1988.
man LDLo unreported 546mg/kg (546mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LCLo inhalation 23gm/m3/56M (23000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Biochemische Zeitschrift. Vol. 115, Pg. 235, 1921.
mouse LD50 intraperitoneal 623mg/kg (623mg/kg)   Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960.
mouse LD50 oral 36mg/kg (36mg/kg)   Archives of Toxicology, Supplement. Vol. 2, Pg. 371, 1979.
mouse LD50 subcutaneous 704mg/kg (704mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.
rabbit LCLo inhalation 59gm/m3 (59000mg/m3)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 230, 1966.
rabbit LD50 skin > 20gm/kg (20000mg/kg)   National Technical Information Service. Vol. AD-A062-138,
rabbit LDLo oral 500mg/kg (500mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 97, Pg. 86, 1923.
rabbit LDLo subcutaneous 800mg/kg (800mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
rat LC50 inhalation 47702mg/m3/4H (47702mg/m3)   Environmental Research. Vol. 40, Pg. 411, 1986.
rat LD50 intraperitoneal 894mg/kg (894mg/kg)   Environmental Research. Vol. 40, Pg. 411, 1986.
rat LD50 oral 695mg/kg (695mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Khigiena i Zdraveopazvane. Hygiene and Sanitation. Vol. 29(5), Pg. 39, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -6.36E+01 deg C   EXP
Boiling Point 61.1 deg C   EXP
log P (octanol-water) 1.97 (none)   EXP
Water Solubility 7950 mg/L 25 EXP
Vapor Pressure 197 mm Hg 25 EXP
Henry's Law Constant 0.00367 atm-m3/mole 24 EXP
Atmospheric OH Rate Constant 1.03E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.