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Substance Name: Dimethyl sulfoxide [USAN:USP:INN:BAN]
RN: 67-68-5
UNII: YOW8V9698H
InChIKey: IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Note

  • A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

Molecular Formula

  • C2-H6-O-S

Molecular Weight

  • 78.1344
 

Classification Codes

  • Anti-Inflammatory (Topical)
  • Antioxidants
  • Cryoprotective Agents
  • Drug / Therapeutic Agent
  • Free Radical Scavengers
  • Human Data
  • Mutation Data
  • Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor Data

Names and Synonyms

Name of Substance

  • Dermasorb
  • Dimethyl sulfoxide
  • Dimethyl sulfoxide [USAN:USP:INN:BAN]

MeSH Heading

  • Dimethyl sulfoxide

Synonyms

  • A 10846
  • AI3-26477
  • Caswell No. 381
  • CCRIS 943
  • Deltan
  • Demasorb
  • Demavet
  • Demeso
  • Demsodrox
  • Dermasorb
  • Dimethyl sulfoxide
  • Dimethyl sulphoxide
  • Dimethyli sulfoxidum
  • Dimethyli sulfoxidum [INN-Latin]
  • Dimethylsulfoxide
  • Dimethylsulfoxyde
  • Dimethylsulfoxyde [INN-French]
  • Dimetil sulfoxido
  • Dimetil sulfoxido [INN-Spanish]
  • Dimetilsolfossido
  • Dimetilsolfossido [DCIT]
  • Dimexide
  • Dipirartril-tropico
  • DMS-70
  • DMS-90
  • DMSO
  • Dolicur
  • Doligur
  • Domoso
  • Domoso (Veterinary)
  • Dromisol
  • Durasorb
  • EC 200-664-3
  • EINECS 200-664-3
  • EPA Pesticide Chemical Code 000177
  • Gamasol 90
  • Herpid
  • HSDB 80
  • Hyadur
  • Infiltrina
  • Kemsol
  • M 176
  • Methane, sulfinylbis-
  • Methyl sulfoxide
  • Methylsulfinylmethane
  • NSC 763
  • NSC-763
  • Rimso-5
  • Rimso-50
  • Somipront
  • SQ 9453
  • Sulfinylbis(methane)
  • Syntexan
  • Topsym
  • Topsym (rescinded)
  • UNII-YOW8V9698H

Systematic Names

  • Dimethyl sulfoxide
  • Methane, 1,1'-sulfinylbis-
  • Methane, sulfinylbis-
  • Methyl sulfoxide
  • Sulfinylbis-methane (9CI)

Superlist Names

  • Dimethyl sulfoxide
  • Methyl sulfoxide

Registry Numbers

CAS Registry Number

  • 67-68-5

FDA UNII

  • YOW8V9698H

Other Registry Numbers

  • 164071-41-4
  • 705301-21-9
  • 8070-53-9

System Generated Number

  • 0000067685

Structure Descriptors

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChIKey

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Smiles

CS(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 100mg/kg (100mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat LDLo intravenous 200mg/kg (200mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1571, 1978.
chicken LD50 oral 12gm/kg (12000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963.
dog LD50 intravenous 2500mg/kg (2500mg/kg) CARDIAC: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: HEMATURIA

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Cancer Chemotherapy Reports. Vol. 31, Pg. 7, 1963.
dog LD50 oral > 10gm/kg (10000mg/kg)   Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
guinea pig LDLo intraperitoneal > 5500mg/kg (5500mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963.
guinea pig LDLo oral > 11gm/kg (11000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963.
mammal (species unspecified) LD50 oral 21400mg/kg (21400mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
man TDLo intravenous 606mg/kg (606mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

GASTROINTESTINAL: NAUSEA OR VOMITING
Lancet. Vol. 2, Pg. 1004, 1980.
mouse LD50 intraperitoneal 2500mg/kg (2500mg/kg)   Russian Pharmacology and Toxicology Vol. 35, Pg. 300, 1972.
mouse LD50 intravenous 3100mg/kg (3100mg/kg) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969.
mouse LD50 oral 7920mg/kg (7920mg/kg)   Chimica Therapeutica. Vol. 3, Pg. 10, 1968.
mouse LD50 skin 50gm/kg (50000mg/kg)   Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
mouse LD50 subcutaneous 14gm/kg (14000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: HEMATURIA
Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
mouse LD50 unreported 12gm/kg (12000mg/kg)   United States Patent Document. Vol. #4767763,
rat LD50 intraperitoneal 8200mg/kg (8200mg/kg)   Food and Chemical Toxicology. Vol. 22, Pg. 665, 1984.
rat LD50 intravenous 5360mg/kg (5360mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 7, Pg. 104, 1965.
rat LD50 oral 14500mg/kg (14500mg/kg) SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969.
rat LD50 skin 40gm/kg (40000mg/kg)   Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967.
rat LD50 subcutaneous 12gm/kg (12000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1050, 1964.
rat LD50 unreported 1300mg/kg (1300mg/kg)   National Technical Information Service. Vol. AD-A159-418,
women TDLo skin 1800mg/kg (1800mg/kg) BLOOD: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Veterinary and Human Toxicology. Vol. 40, Pg. 87, 1998.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 18.5 deg C   EXP
Boiling Point 189 deg C   EXP
log P (octanol-water) -1.35E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 0.61 mm Hg 25 EXP
Henry's Law Constant 1.51E-09 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 6.20E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.