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Substance Name: Fluocinolone acetonide [USAN:USP:INN:JAN]
RN: 67-73-2
UNII: 0CD5FD6S2M
InChIKey: FEBLZLNTKCEFIT-VSXGLTOVSA-N
Note
- A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Molecular Formula
- C24-H30-F2-O6
Molecular Weight
- 452.491
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Drug / Therapeutic Agent
- Glucocorticoid
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Fluocinolone acetonide
- Fluocinolone acetonide [USAN:USP:INN:JAN]
MeSH Heading
- Fluocinolone acetonide
Synonyms
- 6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide
- 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone
- 6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
- 6alpha-Fluorotriamcinolone acetonide
- Acetonida de fluocinolona
- Acetonida de fluocinolona [INN-Spanish]
- Acetonide de fluocinolone
- Acetonide de fluocinolone [INN-French]
- Capex
- CCRIS 3250
- Coriphate
- Cortiplastol
- Derma-Smoothe/FS
- Dermalar
- Dermatin (steroid)
- EINECS 200-668-5
- Flucinar
- Flucort
- Fluocet
- Fluocinolonacetonidum
- Fluocinolone 16,17-acetonide
- Fluocinolone acetonide
- Fluocinolone acetonide intravitreal implant
- Fluocinolone acetonide [DCIT]
- Fluocinoloni acetonidum
- Fluocinoloni acetonidum [INN-Latin]
- Fluonid
- Fluotrex
- Fluovitif
- Flupollon
- Fluzon [Steroid]
- FS
- FS Shampoo
- HSDB 3083
- Iluvien
- Jellin
- Localyn
- Localyn Syntex
- NSC 92339
- Omniderm
- Percutina
- Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
- Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
- Prodermin
- Radiocin
- Retisert
- RS 1401AT
- RS-1401 AT
- Sinalar
- Synalar
- Synalar-HP
- Synamol
- Synandone
- Synandrone
- Synemol
- Synotic
- Synsac
- Tefunote
- UNII-0CD5FD6S2M
Systematic Names
- Fluocinolone acetonide
- Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
- Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone (8CI)
Mixture Name
- Neo-Synalar
Registry Numbers
CAS Registry Number
- 67-73-2
FDA UNII
- 0CD5FD6S2M
System Generated Number
- 0000067732
Structure Descriptors
InChI
InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1InChIKey
FEBLZLNTKCEFIT-VSXGLTOVSA-NSmiles
CC1(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | subcutaneous | > 3170mg/kg (3170mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. | |
mouse | LD50 | intraperitoneal | 103mg/kg (103mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. | |
mouse | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. | |
mouse | LD50 | subcutaneous | 200mg/kg (200mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. | |
rat | LD50 | intraperitoneal | 42mg/kg (42mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. | |
rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. | |
rat | LD50 | subcutaneous | 108mg/kg (108mg/kg) | Drugs in Japan Vol. 6, Pg. 694, 1982. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 265-266 | deg C | EXP | |
log P (octanol-water) | 2.48 | (none) | EXP | |
Water Solubility | 11 | mg/L | 25 | EST |
Vapor Pressure | 1.00E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 1.96E-12 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 7.80E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.