Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: Fluocinolone acetonide [USAN:USP:INN:JAN]
RN: 67-73-2
UNII: 0CD5FD6S2M
InChIKey: FEBLZLNTKCEFIT-VSXGLTOVSA-N

Note

  • A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732).

Molecular Formula

  • C24-H30-F2-O6

Molecular Weight

  • 452.491
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Mutation Data
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Fluocinolone acetonide
  • Fluocinolone acetonide [USAN:USP:INN:JAN]

MeSH Heading

  • Fluocinolone acetonide

Synonyms

  • 6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide
  • 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone
  • 6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
  • 6alpha-Fluorotriamcinolone acetonide
  • Acetonida de fluocinolona
  • Acetonida de fluocinolona [INN-Spanish]
  • Acetonide de fluocinolone
  • Acetonide de fluocinolone [INN-French]
  • Capex
  • CCRIS 3250
  • Coriphate
  • Cortiplastol
  • Derma-Smoothe/FS
  • Dermalar
  • Dermatin (steroid)
  • EINECS 200-668-5
  • Flucinar
  • Flucort
  • Fluocet
  • Fluocinolonacetonidum
  • Fluocinolone 16,17-acetonide
  • Fluocinolone acetonide
  • Fluocinolone acetonide intravitreal implant
  • Fluocinolone acetonide [DCIT]
  • Fluocinoloni acetonidum
  • Fluocinoloni acetonidum [INN-Latin]
  • Fluonid
  • Fluotrex
  • Fluovitif
  • Flupollon
  • Fluzon [Steroid]
  • FS
  • FS Shampoo
  • HSDB 3083
  • Iluvien
  • Jellin
  • Localyn
  • Localyn Syntex
  • NSC 92339
  • Omniderm
  • Percutina
  • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Prodermin
  • Radiocin
  • Retisert
  • RS 1401AT
  • RS-1401 AT
  • Sinalar
  • Synalar
  • Synalar-HP
  • Synamol
  • Synandone
  • Synandrone
  • Synemol
  • Synotic
  • Synsac
  • Tefunote
  • UNII-0CD5FD6S2M

Systematic Names

  • Fluocinolone acetonide
  • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone

Mixture Name

  • Neo-Synalar

Registry Numbers

CAS Registry Number

  • 67-73-2

FDA UNII

  • 0CD5FD6S2M

System Generated Number

  • 0000067732

Structure Descriptors

InChI

InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChIKey

FEBLZLNTKCEFIT-VSXGLTOVSA-N

Smiles

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous > 3170mg/kg (3170mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse LD50 intraperitoneal 103mg/kg (103mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse LD50 subcutaneous 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.
rat LD50 intraperitoneal 42mg/kg (42mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.
rat LD50 subcutaneous 108mg/kg (108mg/kg)   Drugs in Japan Vol. 6, Pg. 694, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 265-266 deg C   EXP
log P (octanol-water) 2.48 (none)   EXP
Water Solubility 11 mg/L 25 EST
Vapor Pressure 1.00E-13 mm Hg 25 EST
Henry's Law Constant 1.96E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.80E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.