Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Dicyclomine hydrochloride [USP]
RN: 67-92-5
UNII: CQ903KQA31
InChIKey: GUBNMFJOJGDCEL-UHFFFAOYSA-N

Note

  • A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.

Molecular Formula

  • C19-H35-N-O2.Cl-H

Molecular Weight

  • 345.9514
 

Classification Codes

  • Anticholinergic
  • Drug / Therapeutic Agent
  • Human Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Dicyclomine hydrochloride [USP]

Synonyms

  • (Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride
  • 1-Cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester hydrochlorid
  • 1-Cyclohexyl-cyclohexan-1-carbonsaeure-2-diaethylaminoaethylester hydrochlorid [German]
  • 2-(Diethylamino)ethyl (bicyclohexyl)-1-carboxylate hydrochloride
  • 2-Diethylaminoethyl bicyclohexyl-1-carboxylate hydrochloride
  • AI3-18105
  • Ametil
  • Antispas
  • Atumin
  • Benacol
  • Bentomine
  • Bentyl
  • Bentyl preservative free
  • beta-Diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate hydrochloride
  • beta-Diethylaminoethyl-1-cyclohexylcyclohexanecarboxylate hydrochloride
  • beta-Diethylaminoethyl-1-cyclohexylhexahydrobenzoate hydrochloride
  • Bis(cyclohexyl)carboxylic acid diethylaminoethyl ester hydrochloride
  • Cloridrato dell'estere beta-dietil aminoetilico dell'acido cicloesil-1-cicloesancarbossilico
  • Cyclopam
  • Di-syntramine
  • Dibent
  • Dicyclomine HCl
  • Dicyclomine hydrochloride
  • Dicyclomine hydrochloride (preservative-free)
  • Dicycloverin hydrochloride
  • Dicycloverine hydrochloride
  • Diethylaminocarbethoxybicyclohexyl hydrochloride
  • Diocyl hydrochloride
  • Dyspas
  • EINECS 200-671-1
  • Icramin
  • Kolantyl hydrochloride
  • Mamiesan
  • Merbentyl
  • NSC 404381
  • Oxityl-P
  • Procyclomin
  • Sawamin
  • Spasmoject
  • Stannitol
  • UNII-CQ903KQA31
  • Wyovin hydrochloride

Systematic Names

  • (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride
  • (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
  • (2-(((1,1'-Bicyclohexyl)-1-ylcarbonyl)oxy)ethyl)diethylammonium chloride
  • (Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride

Registry Numbers

CAS Registry Number

  • 67-92-5

FDA UNII

  • CQ903KQA31

Other Registry Number

  • 79988-11-7

Related Registry Number

  • 77-19-0 (Parent)

System Generated Number

  • 0000067925

Molecular Formulas

Molecular Formula

  • C19-H35-N-O2.Cl-H

Molecular Formula Fragments

  • C19-H35-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H

InChIKey

GUBNMFJOJGDCEL-UHFFFAOYSA-N

Smiles

C1(C2CCCCC2)(C(OCCN(CC)CC)=O)CCCCC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo oral 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
British Medical Journal. Vol. 288, Pg. 901, 1984.
mouse LD50 intravenous 31500ug/kg (31.5mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1119, 1961.
mouse LD50 oral 625mg/kg (625mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 305, 1950.
mouse LD50 subcutaneous 1900ug/kg (1.9mg/kg)   Farmaco. Scienza e Tecnica. Vol. 7, Pg. 448, 1952.
rabbit LD50 intravenous 35mg/kg (35mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 305, 1950.
rat LD50 oral 1290mg/kg (1290mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 1954, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 165 deg C   EXP
log P (octanol-water) 3.980 (none)   EST
Water Solubility 2.50E+05 mg/L   EXP
Atmospheric OH Rate Constant 4.80E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.