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Substance Name: Crenolanib [USAN:INN]
RN: 670220-88-9
UNII: LQF7I567TQ
InChIKey: DYNHJHQFHQTFTP-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. (NCI Thesaurus)

Molecular Formula

  • C26-H29-N5-O2

Molecular Weight

  • 443.5481
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • Crenolanib [USAN:INN]

Synonyms

  • ARO-002
  • CP-868,596
  • Crenolanib
  • UNII-LQF7I567TQ

Registry Numbers

CAS Registry Number

  • 670220-88-9

FDA UNII

  • LQF7I567TQ

System Generated Number

  • 0670220889

Structure Descriptors

InChI

1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3

InChIKey

DYNHJHQFHQTFTP-UHFFFAOYSA-N

Smiles

CC1(COc2ccc3c(c2)ncn3c4ccc5cccc(N6CCC(N)CC6)c5n4)COC1