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Substance Name: Procarbazine [INN:BAN]
RN: 671-16-9
UNII: 35S93Y190K
InChIKey: CPTBDICYNRMXFX-UHFFFAOYSA-N

Note

  • An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

Molecular Formula

  • C12-H19-N3-O

Molecular Weight

  • 221.3021
 

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Procarbazine
  • Procarbazine [INN:BAN]

MeSH Heading

  • Procarbazine

Synonyms

  • 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
  • 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine
  • 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide
  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-
  • BRN 0958270
  • CB 400-497
  • CCRIS 2389
  • EINECS 211-582-2
  • HSDB 3250
  • Ibenzmethyzin
  • MIH
  • N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide
  • N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine
  • N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
  • N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide
  • Natulan
  • NSC-77213
  • p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide
  • p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide
  • p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-
  • PCX
  • Procarbazin
  • Procarbazin [German]
  • Procarbazina
  • Procarbazina [INN-Spanish]
  • Procarbazine
  • Procarbazinum
  • Procarbazinum [INN-Latin]
  • Ro 4-6467
  • Ro 4-6467/1
  • UNII-35S93Y190K

Systematic Names

  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-
  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)- (9CI)
  • p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-
  • Procarbazine

Superlist Names

  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-
  • Procarbazine

Registry Numbers

CAS Registry Number

  • 671-16-9

FDA UNII

  • 35S93Y190K

Related Registry Number

  • 366-70-1 (mono-hydrochloride)

System Generated Number

  • 0000671169

Structure Descriptors

InChI

1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)

InChIKey

CPTBDICYNRMXFX-UHFFFAOYSA-N

Smiles

c1(C(NC(C)C)=O)ccc(CNNC)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 614mg/kg (614mg/kg)   JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
rat LD50 intraperitoneal > 400mg/kg (400mg/kg)   Advances in Teratology. Vol. 3, Pg. 181, 1968.
rat LD50 unreported 350mg/kg (350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 363, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.08 (none)   EXP
Water Solubility 1420 mg/L 25 EST
Henry's Law Constant 8.92E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.54E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.