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Substance Name: 2,3-Dihydro-1H-imidazo(1,2-b)pyrazole
RN: 6714-29-0
UNII: MX6Z942BKY
InChIKey: KPMVHELZNRNSMN-UHFFFAOYSA-N

Note

  • Inhibitor of DNA synthesis.

Classification Codes

  • Antineoplastic Agents
  • Mutation Data

Molecular Formula

  • C5-H7-N3

Molecular Weight

  • 109.1313
 
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Names and Synonyms

Name of Substance

  • 2,3-Dihydro-1H-imidazo(1,2-b)pyrazole

Synonyms

  • 1H-Pyrazolo(2,3-a)imidazole, 2,3-dihydro-
  • 2,3-Dihydro-1H-imidazo(1,2-b)pyrazole
  • AI3-63108
  • BA 21381
  • BRN 0742753
  • EINECS 229-769-2
  • Imidazolepyrazole
  • IMPY
  • IMPY (antitumor agent)
  • NSC 174124
  • NSC 51143
  • NSC 641280
  • Pyrazolo(2,3-a)imidazolidine
  • Pyrazoloimidazole
  • UNII-MX6Z942BKY

Systematic Names

  • 1H-Imidazo(1,2-b)pyrazole, 2,3-dihydro-
  • 2,3-Dihydro-1H-imidazo(1,2-b)pyrazole

Registry Numbers

CAS Registry Number

  • 6714-29-0

FDA UNII

  • MX6Z942BKY

System Generated Number

  • 0006714290

Structure Descriptors

InChI

1S/C5H7N3/c1-2-7-8-4-3-6-5(1)8/h1-2,6H,3-4H2

InChIKey

KPMVHELZNRNSMN-UHFFFAOYSA-N

Smiles

c1cnn2c1NCC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 400mg/kg (400mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Cancer Treatment Reports. Vol. 64, Pg. 1031, 1980.
mouse LD50 intraperitoneal 410mg/kg (410mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 intravenous 993mg/kg (993mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
Cancer Treatment Reports. Vol. 64, Pg. 1031, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.25 (none)   EXP
Water Solubility 1.79E+05 mg/L 25 EST
Vapor Pressure 0.169 mm Hg 25 EST
Henry's Law Constant 2.69E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.08E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.