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Substance Name: Perhexiline maleate [USAN]
RN: 6724-53-4
UNII: K7V8Y90G0H
InChIKey: JDZOTSLZMQDFLG-BTJKTKAUSA-N

Note

  • Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.

Molecular Formula

  • C19-H35-N.C4-H4-O4

Molecular Weight

  • 393.564
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Vasodilator (Coronary)
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Names and Synonyms

Name of Substance

  • Perhexiline maleate
  • Perhexiline maleate [USAN]

Synonyms

  • 2-(2,2-Dicyclohexylethyl)piperidine acid maleate
  • 2-(2,2-Dicyclohexylethyl)piperidine maleate
  • 2-(2,2-Dicyclohexylethyl)piperidine maleate (1:1)
  • CCRIS 5491
  • EINECS 229-775-5
  • Perhexiline maleate
  • Pexid
  • UNII-K7V8Y90G0H

Systematic Names

  • 2-(2,2-Dicyclohexylethyl)piperidinium hydrogen maleate
  • Perhexiline maleate
  • Piperidine, 2-(2,2-dicyclohexylethyl)-, (Z)-2-butenedioate (1:1)
  • Piperidine, 2-(2,2-dicyclohexylethyl)-, maleate (1:1)

Registry Numbers

CAS Registry Number

  • 6724-53-4

FDA UNII

  • K7V8Y90G0H

System Generated Number

  • 0006724534

Molecular Formulas

Molecular Formula

  • C19-H35-N.C4-H4-O4

Molecular Formula Fragments

  • C19-H35-N
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

JDZOTSLZMQDFLG-BTJKTKAUSA-N

Smiles

C1(CCCCC1)C(C1CCCCC1)C[C@@H]1NCCCC1.C(\C=C/C(=O)O)(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 4693mg/kg/3Y (4693mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
New Zealand Medical Journal. Vol. 96, Pg. 202, 1983.
man TDLo oral 636mg/kg/89D- (636mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
British Journal of Clinical Practice. Vol. 31, Pg. 136, 1977.
mouse LD50 intraperitoneal 107mg/kg (107mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
mouse LD50 intraperitoneal 107mg/kg (107mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
mouse LD50 oral 2641mg/kg (2641mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 337, 1977.
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
rat LD50 intraperitoneal 106mg/kg (106mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
rat LD50 intraperitoneal 106mg/kg (106mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.
rat LD50 oral 2150mg/kg (2150mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 337, 1977.
rat LD50 oral 2150mg/kg (2150mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 337, 1977.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 83, 1981.