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Substance Name: Neothramycins
RN: 67298-49-1
InChIKey: FXMOIYLVKOALHC-UHFFFAOYSA-N

Note

  • Belong to anthramycin group of antibiotics possessing a benzodiazepine structure.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C13-H14-N2-O4

Molecular Weight

  • 262.264
 
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Names and Synonyms

Name of Substance

  • Neothramycins

Synonyms

  • 1,2,3,11a-Tetrahydro-3,8-dihydroxy-7-methoxy-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one
  • Neothramycin
  • NSC 285223

Systematic Name

  • Neothramycin

Registry Numbers

CAS Registry Number

  • 67298-49-1

System Generated Number

  • 0067298491

Structure Descriptors

InChI

1S/C13H14N2O4/c1-19-11-4-8-9(5-10(11)16)14-6-7-2-3-12(17)15(7)13(8)18/h4-7,12,16-17H,2-3H2,1H3

InChIKey

FXMOIYLVKOALHC-UHFFFAOYSA-N

Smiles

C1(N2[C@@H](CC[C@@H]2C=Nc2c1cc(c(O)c2)OC)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 22mg/kg (22mg/kg)   Journal of Antibiotics. Vol. 35, Pg. 1093, 1982.
mouse LD50 intravenous 23100ug/kg (23.1mg/kg)   Journal of Antibiotics. Vol. 35, Pg. 1093, 1982.
mouse LD50 oral 100mg/kg (100mg/kg)   Journal of Antibiotics. Vol. 35, Pg. 1093, 1982.