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Substance Name: Phenprobamate [INN:BAN:DCF:JAN]
RN: 673-31-4
UNII: UJZ473TPS0
InChIKey: CAMYKONBWHRPDD-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H13-N-O2

Molecular Weight

  • 179.2177
 
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Names and Synonyms

Name of Substance

  • Phenprobamate
  • Phenprobamate [INN:BAN:DCF:JAN]

Synonyms

  • 1-Carbamoyloxy-3-phenylpropane
  • 3-Phenyl-1-propanol carbamate
  • 3-Phenylpropyl carbamate
  • Actiphan
  • Actozine
  • Ansepron
  • Benzenepropanol carbamate
  • BRN 1959273
  • Carbamic acid, 3-phenylpropyl ester
  • EINECS 211-606-1
  • Eirenal
  • Extacol
  • Fenprobamato
  • Fenprobamato [INN-Spanish]
  • gamma-Phenylpropyl carbamate
  • gamma-Phenylpropylcarbamat
  • gamma-Phenylpropylcarbamat [German]
  • HG 532
  • MH 532
  • MH-532
  • Nelaxan
  • NSC 44682
  • NSC 50538
  • NSC 64270
  • Palmita
  • Phenprobamate
  • Phenprobamatum
  • Phenprobamatum [INN-Latin]
  • Proformiphen
  • Qumamquil
  • Spantol
  • Tranquil
  • UNII-UJZ473TPS0

Systematic Names

  • 1-Propanol, 3-phenyl-, carbamate
  • 3-Phenyl-1-propanol carbamate
  • Benzenepropanol, carbamate (9CI)
  • Phenprobamate

Registry Numbers

CAS Registry Number

  • 673-31-4

FDA UNII

  • UJZ473TPS0

System Generated Number

  • 0000673314

Structure Descriptors

InChI

1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12)

InChIKey

CAMYKONBWHRPDD-UHFFFAOYSA-N

Smiles

c1ccc(cc1)CCCOC(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 510mg/kg (510mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 143, 1959.
guinea pig LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 143, 1959.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 intravenous 320mg/kg (320mg/kg)   Merck Index. Vol. 10, Pg. 1047, 1983.
mouse LD50 oral 840mg/kg (840mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 340, 1962.
rabbit LD50 intraperitoneal 285mg/kg (285mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 402, 1972.
rabbit LD50 oral 1125mg/kg (1125mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 402, 1972.
rat LD50 intraperitoneal 275mg/kg (275mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 140, 1959.
rat LD50 oral 1110mg/kg (1110mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 856, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 102 deg C   EXP
log P (octanol-water) 1.96 (none)   EXP
Water Solubility 1180 mg/L 25 EST
Vapor Pressure 2.39E-03 mm Hg 25 EST
Henry's Law Constant 5.63E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.56E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.