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Substance Name: Ufenamate [INN:JAN]
RN: 67330-25-0
UNII: 8Z7O7C1SLZ
InChIKey: JDLSRXWHEBFHNC-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H18-F3-N-O2

Molecular Weight

  • 337.339
 
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Names and Synonyms

Name of Substance

  • Flufenamic acid butyl ester
  • Ufenamate
  • Ufenamate [INN:JAN]

Synonyms

  • Anthranilic acid, N-(alpha,alpha,alpha-trifluoro-m-tolyl)-, butyl ester
  • BRN 2768727
  • Butyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate
  • Butyl flufenamate
  • Butyl o-((m-(trifluoromethyl)phenyl)amino)benzoate
  • EC 614-050-1
  • HF 264
  • N-(alpha,alpha,alpha-Trifluoro-m-tolyl)anthranilic acid butyl ester
  • Ufenamate
  • Ufenamato
  • Ufenamato [Spanish]
  • Ufenamatum
  • Ufenamatum [Latin]
  • UNII-8Z7O7C1SLZ

Systematic Names

  • Benzoic acid, 2-((3-(trifluoromethyl)phenyl)amino)-, butyl ester
  • Butyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate
  • Butyl N-(alpha,alpha,alpha-trifluoro-m-tolyl)anthranilate

Registry Numbers

CAS Registry Number

  • 67330-25-0

FDA UNII

  • 8Z7O7C1SLZ

System Generated Number

  • 0067330250

Structure Descriptors

InChI

1S/C18H18F3NO2/c1-2-3-11-24-17(23)15-9-4-5-10-16(15)22-14-8-6-7-13(12-14)18(19,20)21/h4-10,12,22H,2-3,11H2,1H3

InChIKey

JDLSRXWHEBFHNC-UHFFFAOYSA-N

Smiles

c1(c(C(OCCCC)=O)cccc1)Nc1cc(ccc1)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 1500mg/kg (1500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
dog LD50 oral > 16gm/kg (16000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
dog LD50 skin > 1gm/kg (1000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
dog LD50 subcutaneous 9300mg/kg (9300mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
mouse LD50 intraperitoneal 4100mg/kg (4100mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
mouse LD50 intravenous 610mg/kg (610mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
mouse LD50 oral 3100mg/kg (3100mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
mouse LD50 skin > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 160, 1990.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 160, 1990.
rabbit LD50 intraperitoneal 11500mg/kg (11500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rabbit LD50 intraperitoneal 11500mg/kg (11500mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rabbit LD50 oral 4800mg/kg (4800mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rabbit LD50 skin > 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rabbit LD50 subcutaneous > 10gm/kg (10000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rat LD50 intraperitoneal 4550mg/kg (4550mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rat LD50 intravenous 650mg/kg (650mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rat LD50 oral 510mg/kg (510mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ANTIPSYCHOTIC
Oyo Yakuri. Pharmacometrics. Vol. 18, Pg. 845, 1979.
rat LD50 skin > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 160, 1990.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 197, 1995.