Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Ketamine [INN:BAN]
RN: 6740-88-1
UNII: 690G0D6V8H
InChIKey: YQEZLKZALYSWHR-UHFFFAOYSA-N

Note

  • A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

Molecular Formula

  • C13-H16-Cl-N-O

Molecular Weight

  • 237.7284
 

Classification Codes

Classification Codes

  • Analgesics
  • Anesthetics
  • Anesthetics, Dissociative
  • Anesthetics, General
  • Anesthetics, Intravenous
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Excitatory Amino Acid Agents
  • Excitatory Amino Acid Antagonists
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule III

Names and Synonyms

Name of Substance

  • Ketamine
  • Ketamine [INN:BAN]

MeSH Heading

  • Ketamine

Synonyms

  • (+-)-Ketamine
  • 2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
  • 2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
  • BRN 2216965
  • Cetamina
  • Cetamina [INN-Spanish]
  • CI 581 base
  • CLSTA 20
  • Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+-)-
  • dl-Ketamine
  • EC 229-804-1
  • EINECS 229-804-1
  • HSDB 2180
  • Ketaject
  • Ketalar
  • Ketamine
  • Ketaminum
  • Ketaminum [INN-Latin]
  • Ketaset
  • NSC 70151
  • Special K
  • Special K [street name]
  • UNII-690G0D6V8H

Systematic Names

  • Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
  • Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+-)-
  • Ketamine

Superlist Names

  • DEA No. 7285
  • Ketamine

Registry Numbers

CAS Registry Number

  • 6740-88-1

FDA UNII

  • 690G0D6V8H

Other Registry Numbers

  • 100477-72-3
  • 33643-45-7
  • 79499-51-7

System Generated Number

  • 0006740881

Structure Descriptors

InChI

1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3

InChIKey

YQEZLKZALYSWHR-UHFFFAOYSA-N

Smiles

CNC1(CCCCC1=O)c2ccccc2Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 400mg/kg (400mg/kg)   British Journal of Anesthesia. Vol. 55, Pg. 457, 1983.
mouse LD50 intravenous 77mg/kg (77mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 119, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 92.5 deg C   EXP
log P (octanol-water) 3.120 (none)   EST
Atmospheric OH Rate Constant 7.71E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.