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Substance Name: Amphetamine, pglu-his-
RN: 67543-14-0
InChIKey: FCWXBPYHBSDGRE-LMARGRMVSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H25-N5-O3

Molecular Weight

  • 383.449
 
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Names and Synonyms

Name of Substance

  • Amphetamine, pglu-his-

Synonyms

  • 4-Imidazolepropionamide, N-(alpha-methylphenethyl)-alpha-((2-oxo-5-pyrrolidinyl)formamido)-
  • BRN 0944184
  • p-Glu-his-amph

Systematic Names

  • L-Histidinamide, 5-oxo-L-prolyl-N-(1-methyl-2-phenylethyl)-
  • L-Histidinamide, 5-oxo-L-propyl-N-(1-methyl-2-phenylethyl)-

Registry Numbers

CAS Registry Number

  • 67543-14-0

System Generated Number

  • 0067543140

Structure Descriptors

InChI

1S/C20H25N5O3/c1-13(9-14-5-3-2-4-6-14)23-17(10-15-11-21-12-22-15)20(28)25-19(27)16-7-8-18(26)24-16/h2-6,11-13,16-17,23H,7-10H2,1H3,(H,21,22)(H,24,26)(H,25,27,28)/t13?,16-,17-/m0/s1

InChIKey

FCWXBPYHBSDGRE-LMARGRMVSA-N

Smiles

C([C@@H](N[C@@H](Cc1ccccc1)C)Cc1c[nH]cn1)(=O)NC([C@H]1NC(CC1)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 intraperitoneal 550mg/kg (550mg/kg)   Biochimie. Vol. 63, Pg. 495, 1981.
mammal (species unspecified) LD50 oral 2400mg/kg (2400mg/kg)   Biochimie. Vol. 63, Pg. 495, 1981.
mouse LD50 intraperitoneal 550mg/kg (550mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 14, Pg. 425, 1979.
mouse LD50 oral 2400mg/kg (2400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 14, Pg. 425, 1979.