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Substance Name: Methylphosphonyl difluoride
RN: 676-99-3
InChIKey: PQIOSYKVBBWRRI-UHFFFAOYSA-N

Note

  • Intermediate in the preparation of cholinesterase inhibitors.

Molecular Formula

  • C-H3-F2-O-P

Molecular Weight

  • 100.0037
 
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Names and Synonyms

Name of Substance

  • Methylphosphonic difluoride
  • Methylphosphonyl difluoride

Synonyms

  • 4-04-00-03508 (Beilstein Handbook Reference)
  • BRN 1739375
  • DF
  • Difluoro
  • Difluoromethylphosphine oxide
  • HSDB 7668
  • Methyl difluorophosphite
  • Methylphosphonic difluoride
  • Methylphosphonyl difluoride
  • Methylphosphonyldifluoride
  • Phosphonodifluoridic acid, methyl-

Systematic Names

  • Phosphonic difluoride, methyl-
  • Phosphonic difluoride, P-methyl-

Registry Numbers

CAS Registry Number

  • 676-99-3

System Generated Number

  • 0000676993

Structure Descriptors

InChI

1S/CH3F2OP/c1-5(2,3)4/h1H3

InChIKey

PQIOSYKVBBWRRI-UHFFFAOYSA-N

Smiles

O=P(F)(F)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 1842mg/m3/30M (1842mg/m3)   Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
dog LCLo inhalation 1842mg/m3/30M (1842mg/m3) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
dog LD50 intravenous 25800ug/kg (25.8mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
guinea pig LCLo inhalation 1600mg/m3 (1600mg/m3)   Toxicologist. Vol. 4, Pg. 22, 1984.
monkey LCLo inhalation 2608mg/m3/30M (2608mg/m3) BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
monkey LD50 intravenous 26900ug/kg (26.9mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LCLo inhalation 1842mg/m3/30M (1842mg/m3) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
mouse LD50 intravenous 114mg/kg (114mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
rat LCLo inhalation 1842mg/m3/30M (1842mg/m3) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
rat LD50 intravenous 13700ug/kg (13.7mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,