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Substance Name: Vinzolidine [INN]
RN: 67699-40-5
UNII: 533U947V6Q
InChIKey: MMRCWWRFYLZGAE-ZBZRSYSASA-N

Note

  • Orally active, semisynthetic vinca alkaloid.

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C48-H58-Cl-N5-O9

Molecular Weight

  • 884.4652
 
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Names and Synonyms

Name of Substance

  • Vinzolidine
  • Vinzolidine [INN]

Synonyms

  • BRN 1070206
  • EINECS 266-915-4
  • UNII-533U947V6Q
  • Vinzolidina
  • Vinzolidina [INN-Spanish]
  • Vinzolidine
  • Vinzolidinum
  • Vinzolidinum [INN-Latin]

Systematic Names

  • 2H-3,7-Methanoazacycloundecino(5,4-b)indole-9-carboxylic acid, 9-((2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-4-(acetyloxy)-3'-(2-chloroethyl)-6,7-didehydro-16-methoxy-1-methyl-2',4'-dioxospiro(aspidospermidine-3,5'-oxazolidin)-15-yl)-5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-, methyl ester, (3R-(3R*,5S*,7R*,9S*))-
  • Vinzolidine

Registry Numbers

CAS Registry Number

  • 67699-40-5

FDA UNII

  • 533U947V6Q

System Generated Number

  • 0067699405

Structure Descriptors

InChI

1S/C48H58ClN5O9/c1-7-44(59)24-29-25-47(42(57)61-6,37-31(14-19-52(26-29)27-44)30-12-9-10-13-34(30)50-37)33-22-32-35(23-36(33)60-5)51(4)39-46(32)16-20-53-18-11-15-45(8-2,38(46)53)40(62-28(3)55)48(39)41(56)54(21-17-49)43(58)63-48/h9-13,15,22-23,29,38-40,50,59H,7-8,14,16-21,24-27H2,1-6H3/t29-,38-,39+,40+,44-,45+,46+,47-,48-/m0/s1

InChIKey

MMRCWWRFYLZGAE-ZBZRSYSASA-N

Smiles

CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@H]7[C@]68CCN9CC=C[C@@](CC)([C@@H](OC(=O)C)[C@@]7%10OC(=O)N(CCCl)C%10=O)[C@@H]89)C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human LDLo intravenous 324ug/kg/3D (0.324mg/kg) BLOOD: AGRANULOCYTOSIS Proceedings of the American Association for Cancer Research. Vol. 29, Pg. 325, 1988.