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Substance Name: Tolpronine hydrochloride
RN: 6775-25-3
InChIKey: ULNVWYGFIUFKDR-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H21-N-O2.Cl-H

Molecular Weight

  • 283.797
 
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Names and Synonyms

Results Name

  • Tolpronine hydrochloride

Synonyms

  • 1(2H)-Pyridineethanol, 3,6-dihydro-alpha-((2-methylphenoxy)methyl)-, hydrochloride
  • 1-(1,2,3,6-Tetrahydropyridino)-3-o-tolyloxypropan-2-ol hydrochloride
  • 1-delta(sup 3)-Piperidino-3-o-toloxypropan-2-ol hydrochloride
  • Proponesin HCl
  • Proponesin hydrochloride
  • Tolpronine hydrochloride

Systematic Name

  • 1(2H)-Pyridineethanol, 3,6-dihydro-alpha-((o-tolyloxy)methyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 6775-25-3

System Generated Number

  • 0006775253

Molecular Formulas

Molecular Formula

  • C15-H21-N-O2.Cl-H

Molecular Formula Fragments

  • C15-H21-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H21NO2.ClH/c1-13-7-3-4-8-15(13)18-12-14(17)11-16-9-5-2-6-10-16;/h2-5,7-8,14,17H,6,9-12H2,1H3;1H

InChIKey

ULNVWYGFIUFKDR-UHFFFAOYSA-N

Smiles

C1CC=CC[N@@]1C[C@@H](O)COc1c(cccc1)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 146mg/kg (146mg/kg)   United States Patent Document. Vol. #3085938,
mouse LD50 oral 330mg/kg (330mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 60, 1958.
mouse LD50 subcutaneous 390mg/kg (390mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 60, 1958.
rat LD50 oral 340mg/kg (340mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 60, 1958.
rat LD50 subcutaneous 1030mg/kg (1030mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacy and Pharmacology. Vol. 10, Pg. 60, 1958.