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Substance Name: Bleomycin hydrochloride [JAN]
RN: 67763-87-5
UNII: 7Z9O46JA4A
InChIKey: BEQASIAARPDOGM-GKQFXSEVSA-O

Molecular Weight

  • 1452.0255
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Name of Substance

  • Bleomycin hydrochloride [JAN]

Synonyms

  • Bleomycin chlorhydrate
  • Bleomycin hydrochloride
  • UNII-7Z9O46JA4A

Systematic Name

  • Bleomycin, hydrochloride

Superlist Name

  • Bleomycin hydrochloride [Bleomycins]

Registry Numbers

CAS Registry Number

  • 67763-87-5

FDA UNII

  • 7Z9O46JA4A

System Generated Number

  • 0067763875

Structure Descriptors

InChI

1S/C55H83N17O21S3.ClH/c1-20-31(69-44(72-42(20)58)25(14-29(57)74)64-15-24(56)43(59)80)48(84)71-33(39(26-16-61-19-65-26)89-54-41(35(76)36(77)51(87-5)93-54)90-53-38(79)40(91-55(60)86)37(78)52(88-6)92-53)49(85)66-22(3)34(75)21(2)45(81)70-32(23(4)73)47(83)63-12-10-30-67-28(18-94-30)50-68-27(17-95-50)46(82)62-11-9-13-96(7)8;/h16-19,21-25,32-41,51-54,64,73,75-79H,9-15,56H2,1-8H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,74,80,81,82,83,84,85,86);1H/p+1/t21-,22+,23-,24-,25-,32-,33-,34-,35+,36+,37+,38+,39-,40+,41+,51-,52+,53+,54-;/m0./s1

InChIKey

BEQASIAARPDOGM-GKQFXSEVSA-O

Smiles

Cl.CO[C@H]1O[C@H](O[C@H]([C@H](NC(=O)c2nc(nc(N)c2C)[C@H](CC(=O)N)NC[C@H](N)C(=O)N)C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](C)O)C(=O)NCCc3nc(cs3)c4nc(cs4)C(=O)NCCC[S+](C)C)c5c[nH]cn5)[C@H](O[C@@H]6O[C@@H](OC)[C@H](O)[C@@H](OC(=O)N)[C@H]6O)[C@H](O)[C@H]1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 190mg/kg (190mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 455, 1975.
mouse LD50 intravenous 281mg/kg (281mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse LD50 subcutaneous 282mg/kg (282mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
rat LD50 intraperitoneal 143mg/kg (143mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 455, 1975.
rat LD50 subcutaneous 252mg/kg (252mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.