Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Isepamicin sulfate [JAN]
RN: 67814-76-0
InChIKey: DDXRHRXGIWOVDQ-MGAUJLSLSA-L

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C22-H43-N5-O12.H2-O4-S

Molecular Weight

  • 665.667
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Isepamicin sulfate
  • Isepamicin sulfate [JAN]

Synonyms

  • 1-N-(S-3-Amino-2-hydroxypropionyl)-gentamicin B sulfate
  • Exacin
  • HAPA-B sulfate
  • Isepacin
  • Isepamicin sulfate
  • Sch 21420 sulfate

Systematic Name

  • D-Streptamine, O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-N(sup 1)-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)

Registry Numbers

CAS Registry Number

  • 67814-76-0

System Generated Number

  • 0067814760

Molecular Formulas

Molecular Formula

  • C22-H43-N5-O12.H2-O4-S

Molecular Formula Fragments

  • C22-H43-N5-O12
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/p-2/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1

InChIKey

DDXRHRXGIWOVDQ-MGAUJLSLSA-L

Smiles

S([O-])(=O)(=O)[O-].O1[C@H](CN)[C@H]([C@H](O)[C@H]([C@H]1O[C@@H]1[C@@H](N)C[C@@H](NC([C@H](CN)O)=O)[C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@H]([C@](CO1)(O)C)NC)O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular > 1800mg/kg (1800mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
dog LD50 intravenous 720mg/kg (720mg/kg)   Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 intramuscular 2508mg/kg (2508mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 intraperitoneal 2244mg/kg (2244mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 intravenous 234mg/kg (234mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 109, 1990.
mouse LD50 subcutaneous 3320mg/kg (3320mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat LD50 intramuscular 2088mg/kg (2088mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat LD50 intraperitoneal 1591mg/kg (1591mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat LD50 intravenous 476mg/kg (476mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 109, 1990.
rat LD50 subcutaneous 3392mg/kg (3392mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.