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Substance Name: Endotoxin, escherichia coli
RN: 67924-63-4

Classification Codes

  • Mutation Data
  • Reproductive Effect
 
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Links to Resources

Names and Synonyms

Name of Substance

  • Endotoxin, escherichia coli

Synonyms

  • E. coli endotoxin
  • Endotoxin, E. coli
  • Endotoxin, E. coli 089
  • Endotoxin, escherichia coli
  • Escherichia coli endotoxin
  • Escherichia coli, endotoxin

Systematic Name

  • Endotoxin, E. coli

Registry Numbers

CAS Registry Number

  • 67924-63-4

System Generated Number

  • 0067924634

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 2200ug/kg (2.2mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: CHANGE IN FORCE OF CONTRACTION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
European Journal of Pharmacology. Vol. 9, Pg. 311, 1970.
cat LDLo intraarterial 3mg/kg (3mg/kg)   Microvascular Research. Vol. 20, Pg. 242, 1980.
cattle LDLo parenteral 400ng/kg (0.0004mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
"Natural Toxins, Proceedings of the International Symposium on Animal, Plant Microbial Toxins 6th, 1979," Eaker, D., and T. Waldstroem, eds., Oxford, UK, Pergamon Press Ltd., 1980. Also published as TOXIA6 Vol. -, Pg. 369, 1980.
dog LD50 intravenous 1mg/kg (1mg/kg) BLOOD: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Circulatory Shock. Vol. 7, Pg. 299, 1980.
dog LDLo unreported 550ug/kg (0.55mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 107, Pg. 777, 1961.
horse/donkey LDLo intraperitoneal 300ug/kg (0.3mg/kg) BLOOD: AGRANULOCYTOSIS

BLOOD: THROMBOCYTOPENIA
Toxicon. Vol. 19, Pg. 189, 1981.
mouse LD50 intraperitoneal 4550ug/kg (4.55mg/kg)   Science. Vol. 229, Pg. 869, 1985.
mouse LD50 intravenous 2mg/kg (2mg/kg)   Journal of General Microbiology. Vol. 86, Pg. 363, 1975.
mouse LD50 parenteral 27500ug/kg (27.5mg/kg)   Experientia. Vol. 35, Pg. 804, 1979.
mouse LD50 subcutaneous 7700mg/kg (7700mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Acta Pathologica Japonica. Vol. 9, Pg. 141, 1959.
mouse LD50 unreported 12500ug/kg (12.5mg/kg)   Toxicon. Vol. 19, Pg. 189, 1981.
rabbit LD50 intravenous 500ug/kg (0.5mg/kg)   Japanese Journal of Medical Science and Biology. Vol. 34, Pg. 54, 1981.
rat LD50 intraperitoneal 7600ug/kg (7.6mg/kg) BLOOD: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN

LIVER: OTHER CHANGES
Circulatory Shock. Vol. 18, Pg. 11, 1986.
rat LD50 intravenous 3700ug/kg (3.7mg/kg)   Japanese Journal of Medical Science and Biology. Vol. 34, Pg. 54, 1981.