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Substance Name: Dimethylformamide
RN: 68-12-2
UNII: 8696NH0Y2X
InChIKey: ZMXDDKWLCZADIW-UHFFFAOYSA-N

Note

  • A formamide in which the amino hydrogens are replaced by methyl groups.

Molecular Formula

  • C3-H7-N-O

Molecular Weight

  • 73.0943
 

Classification Codes

Classification Codes

  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 252
  • 2011 CERCLA Priority List, Rank: 247
  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 100 lb
  • TWA (10 ppm); skin; Not classifiable as a human carcinogen
  • TWA 10 ppm (30 mg/m3); skin

Names and Synonyms

Results Name

  • Dimethylformamide

Name of Substance

  • Dimethylformamide
  • N,N-Dimethylformamide

MeSH Heading

  • Dimethylformamide

Synonyms

  • AI3-03311
  • Caswell No. 366A
  • CCRIS 1638
  • Dimethyl formamide
  • Dimethylamid kyseliny mravenci
  • Dimethylamid kyseliny mravenci [Czech]
  • Dimethylformamid
  • Dimethylformamid [German]
  • Dimethylformamide
  • Dimetilformamide
  • Dimetilformamide [Italian]
  • Dimetylformamidu
  • Dimetylformamidu [Czech]
  • DMF
  • DMF (amide)
  • DMFA
  • Dwumetyloformamid
  • Dwumetyloformamid [Polish]
  • EC 200-679-5
  • EINECS 200-679-5
  • EPA Pesticide Chemical Code 366200
  • Formamide, N,N-dimethyl-
  • Formic acid, amide, N,N-dimethyl-
  • HSDB 78
  • N,N-Dimethyl formamide
  • N,N-Dimethylformamide
  • N,N-Dimethylmethanamide
  • N,N-Dimetilformamida
  • N,N-Dimetilformamida [Spanish]
  • N-Formyldimethylamine
  • NCI-C60913
  • NSC 5356
  • U-4224
  • UNII-8696NH0Y2X

Systematic Names

  • Formamide, N,N-dimethyl-
  • N,N-Dimethylformamide

Superlist Names

  • Dimethyl formamide
  • Dimethylformamide
  • Formamide, N,N-dimethyl-
  • N,N-Dimethylformamide
  • N,N-Dimethylformamide [UN2265] [Flammable liquid]
  • UN2265

Registry Numbers

CAS Registry Number

  • 68-12-2

FDA UNII

  • 8696NH0Y2X

Other Registry Numbers

  • 114057-15-7
  • 15175-63-0
  • 15175-77-6
  • 33513-42-7

System Generated Number

  • 0000068122

Structure Descriptors

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChIKey

ZMXDDKWLCZADIW-UHFFFAOYSA-N

Smiles

N(C=O)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intraperitoneal 500mg/kg (500mg/kg) BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

LIVER: OTHER CHANGES
British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.
dog LD50 intravenous 470mg/kg (470mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
guinea pig LD50 intravenous 1050mg/kg (1050mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
guinea pig LDLo intraperitoneal 4gm/kg (4000mg/kg) LIVER: FATTY LIVER DEGERATION American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.
mouse LC50 inhalation 9400mg/m3/2H (9400mg/m3) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 1, Pg. 54, 1961.
mouse LD50 intramuscular 3900mg/kg (3900mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
mouse LD50 intraperitoneal 650mg/kg (650mg/kg)   Cancer Chemotherapy Reports. Vol. 30, Pg. 9, 1963.
mouse LD50 intravenous 2500mg/kg (2500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
mouse LD50 oral 2900mg/kg (2900mg/kg)   National Technical Information Service. Vol. OTS0521148,
mouse LD50 subcutaneous 4500mg/kg (4500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
rabbit LD50 intraperitoneal 1gm/kg (1000mg/kg) BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.
rabbit LD50 intravenous 1800mg/kg (1800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
rabbit LD50 oral 5gm/kg (5000mg/kg)   National Technical Information Service. Vol. OTS0520699,
rabbit LD50 skin 4720mg/kg (4720mg/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LCLo inhalation 5000ppm/6H (5000ppm)   United States Patent Document. Vol. #5122301,
rat LD skin > 3160mg/kg (3160mg/kg)   National Technical Information Service. Vol. OTS0516779,
rat LD50 intraperitoneal 1400mg/kg (1400mg/kg)   British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.
rat LD50 intraperitoneal 1400mg/kg (1400mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956.
rat LD50 intravenous 2gm/kg (2000mg/kg)   Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
rat LD50 oral 2800mg/kg (2800mg/kg)   Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
rat LD50 subcutaneous 3800mg/kg (3800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965.
rat LD50 unreported > 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -6.04E+01 deg C   EXP
Boiling Point 153 deg C   EXP
pKa Dissociation Constant -0.3 (none)   EXP
log P (octanol-water) -1.01E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 3.87 mm Hg 25 EXP
Henry's Law Constant 7.39E-08 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.75E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.