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Substance Name: Dimethylformamide
RN: 68-12-2
UNII: 8696NH0Y2X
InChIKey: ZMXDDKWLCZADIW-UHFFFAOYSA-N
Note
- A formamide in which the amino hydrogens are replaced by methyl groups.
Molecular Formula
- C3-H7-N-O
Molecular Weight
- 73.0943
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Codes
- 2007 CERCLA Priority List, Rank: 252
- 2011 CERCLA Priority List, Rank: 247
- Overall Carcinogenic Evaluation: Group 3
- Reportable Quantity (RQ) = 100 lb
- TWA (10 ppm); skin; Not classifiable as a human carcinogen
- TWA 10 ppm (30 mg/m3); skin
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Names and Synonyms
Results Name
- Dimethylformamide
Name of Substance
- Dimethylformamide
- N,N-Dimethylformamide
MeSH Heading
- Dimethylformamide
Synonyms
- AI3-03311
- Caswell No. 366A
- CCRIS 1638
- Dimethyl formamide
- Dimethylamid kyseliny mravenci
- Dimethylamid kyseliny mravenci [Czech]
- Dimethylformamid
- Dimethylformamid [German]
- Dimethylformamide
- Dimetilformamide
- Dimetilformamide [Italian]
- Dimetylformamidu
- Dimetylformamidu [Czech]
- DMF
- DMF (amide)
- DMFA
- Dwumetyloformamid
- Dwumetyloformamid [Polish]
- EC 200-679-5
- EINECS 200-679-5
- EPA Pesticide Chemical Code 366200
- Formamide, N,N-dimethyl-
- Formic acid, amide, N,N-dimethyl-
- HSDB 78
- N,N-Dimethyl formamide
- N,N-Dimethylformamide
- N,N-Dimethylmethanamide
- N,N-Dimetilformamida
- N,N-Dimetilformamida [Spanish]
- N-Formyldimethylamine
- NCI-C60913
- NSC 5356
- U-4224
- UNII-8696NH0Y2X
Systematic Names
- Formamide, N,N-dimethyl-
- N,N-Dimethylformamide
Superlist Names
- Dimethyl formamide
- Dimethylformamide
- Formamide, N,N-dimethyl-
- N,N-Dimethylformamide
- N,N-Dimethylformamide [UN2265] [Flammable liquid]
- UN2265
Registry Numbers
CAS Registry Number
- 68-12-2
FDA UNII
- 8696NH0Y2X
Other Registry Numbers
- 114057-15-7
- 15175-63-0
- 15175-77-6
- 33513-42-7
System Generated Number
- 0000068122
Structure Descriptors
InChI
1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3InChIKey
ZMXDDKWLCZADIW-UHFFFAOYSA-NSmiles
N(C=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION LIVER: OTHER CHANGES | British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956. |
dog | LD50 | intravenous | 470mg/kg (470mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
guinea pig | LD50 | intravenous | 1050mg/kg (1050mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
guinea pig | LDLo | intraperitoneal | 4gm/kg (4000mg/kg) | LIVER: FATTY LIVER DEGERATION | American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974. |
mouse | LC50 | inhalation | 9400mg/m3/2H (9400mg/m3) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 1, Pg. 54, 1961. |
mouse | LD50 | intramuscular | 3900mg/kg (3900mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
mouse | LD50 | intraperitoneal | 650mg/kg (650mg/kg) | Cancer Chemotherapy Reports. Vol. 30, Pg. 9, 1963. | |
mouse | LD50 | intravenous | 2500mg/kg (2500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
mouse | LD50 | oral | 2900mg/kg (2900mg/kg) | National Technical Information Service. Vol. OTS0521148, | |
mouse | LD50 | subcutaneous | 4500mg/kg (4500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
rabbit | LD50 | intraperitoneal | 1gm/kg (1000mg/kg) | BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956. |
rabbit | LD50 | intravenous | 1800mg/kg (1800mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
rabbit | LD50 | oral | 5gm/kg (5000mg/kg) | National Technical Information Service. Vol. OTS0520699, | |
rabbit | LD50 | skin | 4720mg/kg (4720mg/kg) | American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. | |
rat | LCLo | inhalation | 5000ppm/6H (5000ppm) | United States Patent Document. Vol. #5122301, | |
rat | LD | skin | > 3160mg/kg (3160mg/kg) | National Technical Information Service. Vol. OTS0516779, | |
rat | LD50 | intraperitoneal | 1400mg/kg (1400mg/kg) | British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956. | |
rat | LD50 | intraperitoneal | 1400mg/kg (1400mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Industrial Medicine. Vol. 13, Pg. 51, 1956. |
rat | LD50 | intravenous | 2gm/kg (2000mg/kg) | Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967. | |
rat | LD50 | oral | 2800mg/kg (2800mg/kg) | Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967. | |
rat | LD50 | subcutaneous | 3800mg/kg (3800mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 618, 1965. | |
rat | LD50 | unreported | > 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -6.04E+01 | deg C | EXP | |
Boiling Point | 153 | deg C | EXP | |
pKa Dissociation Constant | -0.3 | (none) | EXP | |
log P (octanol-water) | -1.01E+00 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | 25 | EXP |
Vapor Pressure | 3.87 | mm Hg | 25 | EXP |
Henry's Law Constant | 7.39E-08 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 1.75E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.