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Substance Name: Retinol [INN:BAN]
RN: 68-26-8
UNII: G2SH0XKK91
InChIKey: FPIPGXGPPPQFEQ-OVSJKPMPSA-N
Note
- Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Molecular Formula
- C20-H30-O
Molecular Weight
- 286.456
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Human Data
- Mutation Data
- Reproductive Effect
- Vitamin (Anti-Xerophthalmic)
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Names and Synonyms
Name of Substance
- Retinol [INN:BAN]
- Vitamin A
Synonyms
- (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
- 2,4,6,8-Nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
- 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol
- 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-
- 4-06-00-04133 (Beilstein Handbook Reference)
- A-Mulsal
- A-Sol
- A-Vi-Pel
- A-Vitan
- ACON
- Afaxin
- Agiolan
- Agoncal
- Alcovit A
- All-trans retinol
- all-trans-Retinol
- all-trans-Retinyl alcohol
- all-trans-Vitamin A
- all-trans-Vitamin A alcohol
- Alphalin
- Alphasterol
- Anatola
- Anatola A
- Anti-infective vitamin
- Antixerophthalmic vitamin
- Antixerophthalmisches Vitamin
- Aoral
- Apexol
- Apostavit
- Aquasol A
- Aquasynth
- Atars
- ATAV
- Avibon
- Avita
- Avitol
- Axerol
- Axerophthol
- Axerophtholum
- Bentavit A
- Biosterol
- BRN 0403040
- CCRIS 5444
- Chocola A
- Del-VI-A
- Disatabs Tabs
- Dofsol
- Dohyfral A
- EC 200-683-7
- EINECS 200-683-7
- Epiteliol
- HI-A-Vita
- Homagenets Aoral
- HSDB 815
- Lard factor
- Myvpack
- Nio-A-let
- NSC 122759
- Oleovitamin A
- Ophthalamin
- Plivit A
- Prepalin
- Retinol
- Retinol, all trans-
- Retinolo
- Retinolo [DCIT]
- Retinolum
- Retinolum [INN-Latin]
- Retrovitamin A
- Sehkraft A
- Solu-A
- Super A
- Testavol
- Testavol S
- UNII-G2SH0XKK91
- Vaflol
- Vafol
- Veroftal
- VI-alpha
- Vi-alpha; Vi-alpha
- Vi-Dom-A
- Vio-A
- Vitamin A
- Vitamin A alcohol
- Vitamin A alcohol (VAN)
- Vitamin A alcohol, all-trans-
- Vitamin a oil
- Vitamin A1
- Vitamin A1 alcohol
- Vitamin A1 alcohol, all trans
- Vitamin A1, all-trans-
- Vitamine A
- Vitaminum A
- Vitavel-A
- Vitpex
- Vogan
- Vogan-neu
- Wachstumsvitamin
Systematic Names
- 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol
- Retinol
- Retinol, all trans-
- Vitamin A
Superlist Names
- Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol
- Retinol
- Vitamin A
Registry Numbers
CAS Registry Number
- 68-26-8
FDA UNII
- G2SH0XKK91
Other Registry Numbers
- 13123-33-6
- 17104-91-5
- 5979-23-7
System Generated Number
- 0000068268
Structure Descriptors
InChI
InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+InChIKey
FPIPGXGPPPQFEQ-OVSJKPMPSA-NSmiles
C\C(=C/CO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 912ku/kg/2Y-I (912000iu/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | New England Journal of Medicine. Vol. 294, Pg. 805, 1976. |
child | TDLo | oral | 5475ku/kg/1Y- (5475000iu/kg) | MUSCULOSKELETAL: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION | Clinical Pediatrics Vol. 21, Pg. 435, 1982. |
infant | LDLo | oral | 442ku/kg/11D- (442000iu/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANOREXIA (HUMAN KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Archives of Pathology and Laboratory Medicine. Vol. 108, Pg. 838, 1984. |
man | TDLo | oral | 1217ku/kg/1Y- (1217000iu/kg) | LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" BLOOD: CHANGES IN SPLEEN BLOOD: HEMORRHAGE | Liver Annual. Vol. 12, Pg. 381, 1992. |
mouse | LD50 | intraperitoneal | 1510mg/kg (1510mg/kg) | Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982. | |
mouse | LD50 | oral | 1510mg/kg (1510mg/kg) | "The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984. | |
rat | LD50 | oral | 2gm/kg (2000mg/kg) | Acta Dermato-Venereologica, Supplementum. Vol. 74, Pg. 29, 1975. | |
women | TDLo | oral | 91000iu/kg/26 (91000iu/kg) | LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" BEHAVIORAL: ANOREXIA (HUMAN SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | American Journal of Medicine. Vol. 97, Pg. 523, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 63.5 | deg C | EXP | |
log P (octanol-water) | 5.68 | (none) | EXP | |
Water Solubility | 0.671 | mg/L | 25 | EST |
Vapor Pressure | 7.50E-08 | mm Hg | 25 | EST |
Henry's Law Constant | 1.16E-04 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 4.00E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.