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Substance Name: Sulfadiazine [USP:INN:BAN:JAN]
RN: 68-35-9
UNII: 0N7609K889
InChIKey: SEEPANYCNGTZFQ-UHFFFAOYSA-N
Note
- One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Molecular Formula
- C10-H10-N4-O2-S
Molecular Weight
- 250.281
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Antiparasitic Agents
- Antiprotozoal Agents
- Coccidiostats
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Sulfadiazine
- Sulfadiazine [USP:INN:BAN:JAN]
MeSH Heading
- Sulfadiazine
Synonyms
- 2-Sulfanilamidopyrimidin
- 2-Sulfanilamidopyrimidin [German]
- 2-Sulfanilamidopyrimidine
- 5-25-10-00067 (Beilstein Handbook Reference)
- A 306
- A-306 (VAN)
- Adiazin
- Adiazine
- AI3-01047
- BRN 0235192
- Coco-Diazine
- Cremodiazine
- Cremotres
- Debenal
- Deltazina
- Di-Azo-Mul
- Diazin
- Diazolone
- Diazovit
- Diazyl
- Diazyl (VAN)
- EINECS 200-685-8
- Eskadiazine
- Honey diazine
- Lipo-Diazine
- Lipo-Levazine
- Liquadiazine
- Metha-Meridiazine
- Microsulfon
- N(sup 1)-2-Pyrimidinylsulfanilamide
- Neazine
- Neotrizine
- NSC 35600
- Palatrize
- Pecta-diazine, suspension
- Piridisir
- Pirimal
- Pyrimal
- Pyrimidine, 2-sulfanilamido-
- Quadetts
- Quadramoid
- RP 2616
- S.N. 112
- Sanodiazine
- Solfadiazina
- Solfadiazina [DCIT]
- Spofadrizine
- Sterazine
- Sulfadiazene
- Sulfadiazin
- Sulfadiazina
- Sulfadiazina [INN-Spanish]
- Sulfadiazine
- Sulfadiazinum
- Sulfadiazinum [INN-Latin]
- Sulfanilamide, N1-2(1H)-pyrimidinylidene-
- Sulfanilamidopyrimidine
- Sulfapyrimidin
- Sulfapyrimidin [German]
- Sulfapyrimidine
- Sulfatryl
- Sulfazine
- Sulfolex
- Sulfonsol
- Sulfose
- Sulphadiazine
- Sulphadiazine E
- Terfonyl
- Theradiazine
- Thi-Di-Mer
- Tri-Sulfameth
- Trifonamide
- Triple Sulfas
- Trisem
- Truozine
- UNII-0N7609K889
Systematic Names
- Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-
- Sulfadiazine
- Sulfanilamide, N(sup 1)-2-pyrimidinyl-
- Sulfanilamide, N1-2-pyrimidinyl- (8CI)
Mixture Name
- Sulfonamide Duplex
Registry Numbers
CAS Registry Number
- 68-35-9
FDA UNII
- 0N7609K889
Other Registry Number
- 141582-64-1
System Generated Number
- 0000068359
Structure Descriptors
InChI
InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)InChIKey
SEEPANYCNGTZFQ-UHFFFAOYSA-NSmiles
Nc1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 1800mg/kg/5D- (1800mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA ENDOCRINE: HYPOGLYCEMIA | Postgraduate Medical Journal. Vol. 53, Pg. 103, 1977. |
child | TDLo | unreported | 138mg/kg (138mg/kg) | KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED BEHAVIORAL: GENERAL ANESTHETIC | Postgraduate Medical Journal. Vol. 53, Pg. 103, 1977. |
dog | LD | oral | > 5gm/kg (5000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 79, Pg. 354, 1943. | |
man | TDLo | oral | 229mg/kg/8D-I (229mg/kg) | GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Israel Journal of Medical Sciences. Vol. 6, Pg. 561, 1970. |
mouse | LD50 | intraperitoneal | 750mg/kg (750mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 109, 1969. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03347, | |
mouse | LD50 | oral | 1500mg/kg (1500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 571, 1971. | |
mouse | LD50 | subcutaneous | 1600mg/kg (1600mg/kg) | Drugs in Japan Vol. 6, Pg. 386, 1982. | |
rat | LD50 | intravenous | 880mg/kg (880mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950. | |
rat | LDLo | intraperitoneal | 446mg/kg (446mg/kg) | Klinische Wochenscrift. Vol. 27, Pg. 449, 1949. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 255.5 dec | deg C | EXP | |
pKa Dissociation Constant | 6.36 | (none) | EXP | |
log P (octanol-water) | -0.09 | (none) | EXP | |
Water Solubility | 77 | mg/L | 25 | EXP |
Vapor Pressure | 4.31E-08 | mm Hg | 25 | EST |
Henry's Law Constant | 1.58E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.80E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.