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Substance Name: Dipyrone [USAN:JAN]
RN: 68-89-3
UNII: VSU62Z74ON
InChIKey: DJGAAPFSPWAYTJ-UHFFFAOYSA-M
Note
- A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable. (From Martindale, The Extra Pharmacopoeia, 30th ed, p13)
Molecular Formula
- C13-H17-N3-O4-S.Na
Molecular Weight
- 333.3424
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
- Tumor Data
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Names and Synonyms
Name of Substance
- Dipyrone
- Dipyrone [USAN:JAN]
- Metamizole sodium [INN]
MeSH Heading
- Dipyrone
Synonyms
- (Antipyrinylmethylamino)methanesulfonic acid sodium salt
- 1-Phenyl-2,3-dimethyl-4-methylamino-5-pyrazolon-N-methanesulfonsaeuren natrium
- 1-Phenyl-2,3-dimethyl-4-methylamino-5-pyrazolon-N-methanesulfonsaeuren natrium [German]
- 1-Phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate sodium
- 1-Phenyl-2,3-dimethylpyrazolone-(5)-4-methylaminomethanesulfonic acid sodium
- 4-Methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone sodium methanesulfonate
- 4-Sodium methanesulfonate methylamine-antipyrine
- Alginodia
- Algocalmin
- Algopyrine
- Aminopyrine sodium sulfonate
- Analgin
- Analgine
- Analginum
- Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt
- ARPF
- Barone
- Bonpyrin
- CCRIS 4443
- Conmel
- Di-podil
- Dimethone
- Diprofarn
- Dipyrone
- Dipyrone [BAN]
- EINECS 200-694-7
- Farmolisina
- Fenildimetil-pirazolon-metilaminometansolfonato sodico
- Fenildimetil-pirazolon-metilaminometansolfonato sodico [Italian]
- Feverall
- Fevonil
- Gifaril
- Keypyrone
- Metamizol
- Metamizol sodico
- Metamizol sodico [INN-Spanish]
- Metamizol sodico [Spanish]
- Metamizole
- Metamizole sodique
- Metamizole sodique [French]
- Metamizole sodique [INN-French]
- Metamizole sodium
- Metamizolnatrium
- Metamizolo
- Metamizolo sodico
- Metamizolo sodico [DCIT]
- Metamizolo [Italian]
- Metamizolum
- Metamizolum natricum
- Metamizolum natricum [INN-Latin]
- Metamizolum natricum [Latin]
- Metapyrin
- Methamizole sodium
- Methampyrone
- Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt
- Methylaminoantipyrine sodium methanesulfonate
- Methylaminophenyldimethylpyrazolone methanesulfonate sodium
- Methylmelubrin
- Metilon
- Narone
- Natrium novaminsulfonicum
- Neo-melubrine
- Neomelurbrin
- Nevralgina
- Noramidopyrine methanesulfonate sodium
- Noramidopyrine methanesulfonate sodium salt
- Noramidopyrinium-methanesulphate natrium
- Noramidopyrinium-methanesulphate natrium [German]
- Noraminophenazone
- Noraminophenazone methanesulfonate sodium salt
- Noraminophenazone sodium mesylate
- Noraminopyrine methanesulfonate sodium
- Novalgetol
- Novalgin
- Novamidazophen
- Novamidazophenum
- Novaminophenazone
- Novaminsulfon
- Novaminsulfone
- Novaminsulfone sodium
- Novaminsulfonium
- Novaminsulfonum
- Noveltex
- Optalgin
- Paralgin
- Pharmalgine
- Phenyl dimethyl pyrazolon methyl aminomethane sodium sulfonate
- Prodolina
- Pyralgin
- Pyretin
- Pyretin (pharmaceutical)
- Pyrojec
- Sodium (antipyrinylmethylamino)methanesulfonate
- Sodium 1-phenyl-2,3-dimethyl-4-methylaminopyrazolon-N-methanesulfonate
- Sodium 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methanesulfonate
- Sodium 4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone 4-methanesulfonate
- Sodium methylaminoantipyrine methanesulfonate
- Sodium noramidopyrine methanesulfonate
- Sodium novaminsulfonate
- Sodium phenyldimethylpyrazolon-methylamino-methane sulfonate
- Sulpin
- Sulpyrin
- Sulpyrine
- Sulpyrinum
- UNII-VSU62Z74ON
Systematic Names
- Dipyrone
- Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt
- Methanesulfonic acid, (antipyrinylmethylamino)-, monosodium salt
- Sodium ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)methanesulphonate
Registry Numbers
CAS Registry Number
- 68-89-3
FDA UNII
- VSU62Z74ON
Other Registry Number
- 57904-20-8
System Generated Number
- 0000068893
Molecular Formulas
Molecular Formula
- C13-H17-N3-O4-S.Na
Molecular Formula Fragments
- C13-H17-N3-O4-S
- COMPONENT
- Na
Structure Descriptors
InChI
1S/C13H17N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1InChIKey
DJGAAPFSPWAYTJ-UHFFFAOYSA-MSmiles
[Na+].CN(CS(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | subcutaneous | 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. | |
mouse | LC50 | inhalation | 37200mg/m3 (37200mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(10), Pg. 36, 1969. | |
mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 107, Pg. 322, 1956. | |
mouse | LD50 | intravenous | 2197mg/kg (2197mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. | |
mouse | LD50 | oral | 2891mg/kg (2891mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. | |
mouse | LD50 | subcutaneous | 69mg/kg (69mg/kg) | Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968. | |
mouse | LD50 | unreported | 2750mg/kg (2750mg/kg) | Journal of Drug Research. Vol. 4, Pg. 89, 1972. | |
rabbit | LD50 | oral | 2150mg/kg (2150mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 47, 1979. |
rabbit | LDLo | subcutaneous | 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. | |
rat | LC | inhalation | > 900mg/m3 (900mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 47, 1979. | |
rat | LD50 | intramuscular | 1625mg/kg (1625mg/kg) | Russian Pharmacology and Toxicology Vol. 51, Pg. 183, 1988. | |
rat | LD50 | intraperitoneal | 2470mg/kg (2470mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 478, 1977. |
rat | LD50 | intravenous | 2182mg/kg (2182mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 703, 1976. | |
rat | LD50 | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. |
rat | LD50 | subcutaneous | 2117mg/kg (2117mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974. |