Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Hexamethylphosphoramide
RN: 680-31-9
UNII: M42TU5843Z
InChIKey: GNOIPBMMFNIUFM-UHFFFAOYSA-N

Note

  • A chemosterilant agent that is anticipated to be a carcinogen.

Molecular Formula

  • C6-H18-N3-O-P

Molecular Weight

  • 179.2022
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Chemosterilants
  • Insect Attractant, Repellent and Chemosterilant
  • Insecticide
  • Mutation Data
  • Pesticides
  • Reproductive Effect
  • Skin / Eye Irritant
  • TSCA Flag S (Substance is Identified in a Final Significant New Use Rule)
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 1 lb
  • Skin; Confirmed Animal Carcinogen with Unknown Relevance to Humans

Names and Synonyms

Name of Substance

  • Hempa
  • Hexamethylphosphoramide
  • HMPA

MeSH Heading

  • Hempa

Synonyms

  • AI3-50882
  • CCRIS 332
  • Eastman Inhibitor HPT
  • EINECS 211-653-8
  • ENT 50882
  • Hempa
  • Hexametapol
  • Hexamethyl phosphoramide
  • Hexamethylfosforamid
  • Hexamethylfosforamid [Czech]
  • Hexamethylorthophosphoric triamide
  • Hexamethylphosphoramide
  • Hexamethylphosphoric acid triamide
  • Hexamethylphosphoric triamide
  • Hexamethylphosphorotriamide
  • Hexamethylphosphotriamide
  • HMPA
  • HMPT
  • HMPTA
  • HSDB 2031
  • N,N,N,N,N,N-Hexamethylphosphoric triamide
  • NSC 113131
  • NSC 7967
  • Phosphoric acid hexamethyltriamide
  • Phosphoric hexamethyltriamide
  • Phosphoric triamide, hexamethyl-
  • Phosphoric tris(dimethylamide)
  • Phosphoryl hexamethyltriamide
  • Tris(dimethylamino)phosphine oxide
  • Tris(dimethylamino)phosphorus oxide
  • Tris-(dimethylamid) kyseliny fosforecne
  • Tris-(dimethylamid) kyseliny fosforecne [Czech]
  • UNII-M42TU5843Z

Systematic Names

  • Hexamethylphosphoramide
  • Hexamethylphosphoric triamide
  • Phosphoric triamide, hexamethyl-
  • Phosphoric triamide, N,N,N',N',N'',N''-hexamethyl-

Superlist Names

  • Hexamethyl phosphoramide
  • Hexamethylphosphoramide
  • Hexamethylphosphoric triamide
  • HMPA
  • phoric triamide, hexamethyl-

Registry Numbers

CAS Registry Number

  • 680-31-9

FDA UNII

  • M42TU5843Z

Other Registry Numbers

  • 24992-55-0
  • 51557-01-8

System Generated Number

  • 0000680319

Structure Descriptors

InChI

1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3

InChIKey

GNOIPBMMFNIUFM-UHFFFAOYSA-N

Smiles

P(=O)(N(C)C)(N(C)C)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 835mg/kg (835mg/kg) BEHAVIORAL: ATAXIA

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Toxicology and Applied Pharmacology. Vol. 16, Pg. 100, 1970.
guinea pig LD50 oral 1600mg/kg (1600mg/kg)   "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
guinea pig LD50 skin 1175mg/kg (1175mg/kg)   "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
mouse LD50 intraperitoneal 1600mg/kg (1600mg/kg)   Progress in Mutation Research. Vol. 1, Pg. 682, 1981.
mouse LD50 intravenous 800mg/kg (800mg/kg)   Chemistry and Industry Vol. (36), Pg. 1529, 1966.
mouse LD50 oral 2400mg/kg (2400mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 70, Pg. 114P, 1974.
quail LD50 oral 1gm/kg (1000mg/kg)   Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
rabbit LD50 skin 2600mg/kg (2600mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 18, Pg. 499, 1971.
rabbit LDLo oral 1500mg/kg (1500mg/kg)   Journal of Economic Entomology. Vol. 48, Pg. 139, 1955.
rat LCLo inhalation 2920mg/m3/4H (2920mg/m3) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: OTHER CHANGES
National Technical Information Service. Vol. OTS0571242,
rat LD50 oral 2650mg/kg (2650mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: HEMATURIA

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Nature. Vol. 211, Pg. 146, 1966.
rat LDLo skin 3500mg/kg (3500mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: HEMATURIA
Nature. Vol. 211, Pg. 146, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 7.2 deg C   EXP
Boiling Point 232.5 deg C   EXP
log P (octanol-water) 0.28 (none)   EXP
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 0.046 mm Hg 25 EXP
Henry's Law Constant 2.00E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.01E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.