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Substance Name: Escin
RN: 6805-41-0
UNII: RUU8G67GQM
InChIKey: YFESOSRPNPYODN-RSMWSHJLSA-N
Note
- Pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of AESCULUS. It inhibits edema formation and decreases vascular fragility.
Molecular Formula
- C54-H84-O23
Molecular Weight
- 2262.5208
Classification Codes
- Antiviral (COVID-19)
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Natural Product
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Escin
MeSH Heading
- Escin
Synonyms
- A-4700
- Aescin
- Aescin [German]
- Aescusan
- Amorphous aescin
- EINECS 229-880-6
- Escin
- Escina
- Escina [Italian]
- Reparilu
- Reparilu [Czech]
- UNII-RUU8G67GQM
Systematic Name
- Escin
Registry Numbers
CAS Registry Number
- 6805-41-0
FDA UNII
- RUU8G67GQM
Other Registry Numbers
- 1394-90-7
- 25255-37-2
- 37-02-5
- 47918-34-3
- 55125-87-6
System Generated Number
- 0006805410
Structure Descriptors
InChI
InChI=1S/2C55H86O24/c2*1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h2*10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+;23-10-/t2*26?,27-,28-,29?,30?,31-,32?,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43+,44+,47+,48+,49-,51+,52-,53-,54-,55+/m11/s1InChIKey
YFESOSRPNPYODN-RSMWSHJLSA-NSmiles
C\C=C(\C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 6700ug/kg (6.7mg/kg) | Drugs in Japan Vol. 6, Pg. APP-2, 1982. | |
mouse | LD50 | intravenous | 2mg/kg (2mg/kg) | Bollettino Chimico Farmaceutico. Vol. 115, Pg. 272, 1976. | |
mouse | LD50 | oral | 165mg/kg (165mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974. | |
mouse | LD50 | subcutaneous | 38590ug/kg (38.59mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974. | |
rabbit | LD50 | intravenous | 2500mg/kg (2500mg/kg) | BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" | Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 280, 1960. |
rat | LD50 | intraperitoneal | 10150ug/kg (10.15mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974. | |
rat | LD50 | intravenous | 1600ug/kg (1.6mg/kg) | Bollettino Chimico Farmaceutico. Vol. 115, Pg. 272, 1976. | |
rat | LD50 | oral | 833mg/kg (833mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974. | |
rat | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 118, 1974. |