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Substance Name: Bepridil hydrochloride
RN: 68099-86-5
UNII: 2TN7FF3W4M
InChIKey: JXBBWYGMTNAYNM-UHFFFAOYSA-N

Note

  • A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.

Molecular Formula

  • C24-H34-N2-O.Cl-H

Molecular Weight

  • 403.0065
 

Classification Codes

  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Vasodilator Agents
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Names and Synonyms

Results Name

  • Bepridil hydrochloride

Name of Substance

  • Bepridil hydrochloride anhydrous

Synonyms

  • 1978CERM
  • Bepridil HCl
  • Bepridil hydrochloride
  • Cordium
  • EINECS 268-472-2
  • UNII-2TN7FF3W4M
  • Vascor

Systematic Names

  • 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, monohydrochloride
  • N-Benzyl-beta-((2-methylpropoxy)methyl)-N-phenylpyrrolidine-1-ethylamine monohydrochloride

Registry Numbers

CAS Registry Number

  • 68099-86-5

FDA UNII

  • 2TN7FF3W4M

Other Registry Number

  • 49571-05-3

Related Registry Number

  • 64706-54-3 (Parent)

System Generated Number

  • 0068099865

Molecular Formulas

Molecular Formula

  • C24-H34-N2-O.Cl-H

Molecular Formula Fragments

  • C24-H34-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChIKey

JXBBWYGMTNAYNM-UHFFFAOYSA-N

Smiles

CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 50600ug/kg (50.6mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 225, Pg. 133, 1977.
mouse LD50 oral 2069mg/kg (2069mg/kg)   Drugs in Japan Vol. -, Pg. 1256, 1995.
rat LD50 oral 6850mg/kg (6850mg/kg)   Drugs in Japan Vol. -, Pg. 1256, 1995.