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Substance Name: Tivozanib hydrochloride [USAN]
RN: 682745-41-1
UNII: 8A9H4VK35Z
InChIKey: RQXMKRRBJITKRN-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. (NCI Thesaurus)

Molecular Formula

  • C22-H19-Cl-N4-O5.Cl-H.H2-O

Molecular Weight

  • 509.3438
 
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Names and Synonyms

Results Name

  • Tivozanib hydrochloride [USAN]

Name of Substance

  • Tivozanib hydrochloride [USAN]
  • Tivozanib monohydrochloride monohydrate

Synonyms

  • Tivozanib HCl hydrate
  • Tivozanib hydrochloride
  • Tivozanib hydrochloride hydrate
  • UNII-8A9H4VK35Z

Registry Numbers

CAS Registry Number

  • 682745-41-1

FDA UNII

  • 8A9H4VK35Z

System Generated Number

  • 0682745411

Structure Descriptors

InChI

1S/C22H19ClN4O5.ClH.H2O/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18;;/h4-11H,1-3H3,(H2,25,26,27,28);1H;1H2

InChIKey

RQXMKRRBJITKRN-UHFFFAOYSA-N