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Substance Name: Amlexanox [USAN:INN:BAN:JAN]
RN: 68302-57-8
UNII: BRL1C2459K
InChIKey: SGRYPYWGNKJSDL-UHFFFAOYSA-N

Note

  • SRA-A antagonist.

Molecular Formula

  • C16-H14-N2-O4

Molecular Weight

  • 298.2966
 

Classification Codes

  • Anti-Allergic
  • Anti-Allergic Agents
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Amlexanox
  • Amlexanox [USAN:INN:BAN:JAN]

Synonyms

  • 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid
  • 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
  • AA 673
  • AA-673
  • Amlexanox
  • Amlexanoxo
  • Amlexanoxo [Spanish]
  • Amlexanoxum
  • Amlexanoxum [Latin]
  • Amoxanox
  • Aphthasol
  • BRN 0556384
  • CCRIS 2686
  • CHX 3673
  • Solfa
  • UNII-BRL1C2459K

Systematic Names

  • 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
  • Amoxanox

Registry Numbers

CAS Registry Number

  • 68302-57-8

FDA UNII

  • BRL1C2459K

System Generated Number

  • 0068302578

Structure Descriptors

InChI

1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)

InChIKey

SGRYPYWGNKJSDL-UHFFFAOYSA-N

Smiles

CC(C)c1ccc2c(c1)c(=O)c3cc(c(nc3o2)N)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 450mg/kg (450mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
mouse LD50 oral 2320mg/kg (2320mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
mouse LD50 oral 2320mg/kg (2320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
mouse LD50 subcutaneous 3310mg/kg (3310mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
rat LD50 intraperitoneal 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
rat LD50 oral 10gm/kg (10000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
rat LD50 oral 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.
rat LD50 subcutaneous 1400mg/kg (1400mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985.