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Substance Name: Amlexanox [USAN:INN:BAN:JAN]
RN: 68302-57-8
UNII: BRL1C2459K
InChIKey: SGRYPYWGNKJSDL-UHFFFAOYSA-N
Note
- SRA-A antagonist.
Molecular Formula
- C16-H14-N2-O4
Molecular Weight
- 298.2966
Classification Codes
- Anti-Allergic
- Anti-Allergic Agents
- Drug / Therapeutic Agent
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Names and Synonyms
Name of Substance
- Amlexanox
- Amlexanox [USAN:INN:BAN:JAN]
Synonyms
- 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid
- 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
- AA 673
- AA-673
- Amlexanox
- Amlexanoxo
- Amlexanoxo [Spanish]
- Amlexanoxum
- Amlexanoxum [Latin]
- Amoxanox
- Aphthasol
- BRN 0556384
- CCRIS 2686
- CHX 3673
- Solfa
- UNII-BRL1C2459K
Systematic Names
- 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
- Amoxanox
Registry Numbers
CAS Registry Number
- 68302-57-8
FDA UNII
- BRL1C2459K
System Generated Number
- 0068302578
Structure Descriptors
InChI
InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)InChIKey
SGRYPYWGNKJSDL-UHFFFAOYSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 450mg/kg (450mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
mouse | LD50 | oral | 2320mg/kg (2320mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. | |
mouse | LD50 | oral | 2320mg/kg (2320mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
mouse | LD50 | subcutaneous | 3310mg/kg (3310mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
rat | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
rat | LD50 | oral | 10gm/kg (10000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. | |
rat | LD50 | oral | 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |
rat | LD50 | subcutaneous | 1400mg/kg (1400mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13, Pg. 6405, 1985. |