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Substance Name: Clofilium phosphate [USAN:INN]
RN: 68379-03-3
UNII: O1IXD77P8S
InChIKey: HBLQZEWZVJXHKQ-UHFFFAOYSA-M

Classification Codes

  • Anti-Arrhythmia Agents
  • Cardiac Depressant (Anti-Arrhythmic)
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C21-H37-Cl-N.H2-O4-P

Molecular Weight

  • 435.9691
 
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Names and Synonyms

Name of Substance

  • Clofilium phosphate [USAN:INN]

Synonyms

  • (4-(p-Chlorophenyl)butyl)diethylheptylammonium phosphate (1:1)
  • Clofilii phosphas
  • Clofilii phosphas [INN-Latin]
  • Clofilium phosphate
  • Fosfato de clofilio
  • Fosfato de clofilio [INN-Spanish]
  • Ly 150378
  • N-(4-(4-Chlorphenyl)butyl)-N,N-diethyl-N-heptyl-ammonium dihydrogenphosphat
  • Phosphate de clofilium
  • Phosphate de clofilium [INN-French]
  • UNII-O1IXD77P8S

Systematic Name

  • Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl-, phosphate (1:1)

Registry Numbers

CAS Registry Number

  • 68379-03-3

FDA UNII

  • O1IXD77P8S

Related Registry Number

  • 68379-02-2 (Parent)

System Generated Number

  • 0068379033

Molecular Formulas

Molecular Formula

  • C21-H37-Cl-N.H2-O4-P

Molecular Formula Fragments

  • C21-H37-Cl-N
  • COMPONENT
  • H2-O4-P

Structure Descriptors

InChI

1S/C21H37ClN.H3O4P/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-5(2,3)4/h14-17H,4-13,18-19H2,1-3H3;(H3,1,2,3,4)/q+1;/p-1

InChIKey

HBLQZEWZVJXHKQ-UHFFFAOYSA-M

Smiles

CCCCCCC[N+](CC)(CC)CCCCc1ccc(cc1)Cl.OP(=O)(O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intravenous 300ug/kg (0.3mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) New Drugs Annual: Cardiovascular Drugs. Vol. 2, Pg. 103, 1984.
mouse LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
New Drugs Annual: Cardiovascular Drugs. Vol. 2, Pg. 103, 1984.
rat LD50 intravenous 33mg/kg (33mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
New Drugs Annual: Cardiovascular Drugs. Vol. 2, Pg. 103, 1984.