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Substance Name: N-Nitroso-N-methylurea
RN: 684-93-5
UNII: W8KW4E3XSU
InChIKey: ZRKWMRDKSOPRRS-UHFFFAOYSA-N
Note
- A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
Molecular Formula
- C2-H5-N3-O2
Molecular Weight
- 103.0805
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Alkylating Agents
- Drug / Therapeutic Agent
- Mutation Data
- Noxae
- Reproductive Effect
- Tumor Data
Superlist Classification Codes
- Overall Carcinogenic Evaluation: Group 2A
- Reasonably Anticipated to be a Carcinogen
- Reportable Quantity (RQ) = 1 lb
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Names and Synonyms
Name of Substance
- Methylnitrosourea
- N-Nitroso-N-methylurea
MeSH Heading
- Methylnitrosourea
Synonyms
- 1-Methyl-1-nitrosomocovina
- 1-Methyl-1-nitrosomocovina [Czech]
- 1-Methyl-1-nitrosourea
- 1-Nitroso-1-methylurea
- AI3-50583
- Carbamide, N-methyl-N-nitroso-
- CCRIS 404
- EINECS 211-678-4
- HSDB 5112
- Methylnitroso-harnstoff
- Methylnitroso-harnstoff [German]
- Methylnitrosouree
- Methylnitrosouree [French]
- MNU
- N-Methyl-N-nitroso-harnstoff
- N-Methyl-N-nitroso-harnstoff [German]
- N-Methyl-N-nitrosourea
- N-Nitroso-N-methyl-harnstoff
- N-Nitroso-N-methyl-harnstoff [German]
- N-Nitroso-N-methylcarbamide
- N-Nitroso-N-methylurea
- Nitrosomethylurea
- NMH
- NMH [German]
- NMU
- NSC 23909
- NSC-23909
- O-Nitroso-N-methyl-harnstoff
- O-Nitroso-N-methyl-harnstoff [German]
- RCRA waste number U177
- SKI 24464
- SRI 859
- UNII-W8KW4E3XSU
Systematic Names
- 1-Methyl-1-nitrosourea
- N-Methyl-N-nitrosourea
- Urea, 1-methyl-1-nitroso- (8CI)
- Urea, N-methyl-N-nitroso-
Superlist Names
- N-Methyl-N-nitrosourea
- N-Nitroso-N-methylurea
- RCRA waste no. U177
- Urea, N-methyl-N-nitroso-
Registry Numbers
CAS Registry Number
- 684-93-5
FDA UNII
- W8KW4E3XSU
Other Registry Numbers
- 126742-50-5
- 820-60-0
System Generated Number
- 0000684935
Structure Descriptors
InChI
InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)InChIKey
ZRKWMRDKSOPRRS-UHFFFAOYSA-NSmiles
CN(N=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
hamster | LD50 | subcutaneous | 113mg/kg (113mg/kg) | British Journal of Cancer. Vol. 29, Pg. 359, 1974. | |
hamster | LDLo | intravenous | 42mg/kg (42mg/kg) | Journal of Pathology and Bacteriology. Vol. 92, Pg. 35, 1966. | |
mammal (species unspecified) | LD50 | intravenous | 110mg/kg (110mg/kg) | Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975. | |
mammal (species unspecified) | LD50 | oral | 110mg/kg (110mg/kg) | Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975. | |
mouse | LD50 | intraperitoneal | 144mg/kg (144mg/kg) | Cancer Research. Vol. 30, Pg. 11, 1970. | |
rat | LD50 | intraperitoneal | 110mg/kg (110mg/kg) | Nature. Vol. 222, Pg. 1064, 1969. | |
rat | LD50 | intravenous | 108mg/kg (108mg/kg) | Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. Vol. 257, Pg. 296, 1967. | |
rat | LD50 | oral | 110mg/kg (110mg/kg) | Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967. | |
rat | LDLo | implant | 30mg/kg (30mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Chemico-Biological Interactions. Vol. 5, Pg. 139, 1972. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 123.5 dec | deg C | EXP | |
log P (octanol-water) | -0.03 | (none) | EXP | |
Water Solubility | 1.44E+04 | mg/L | 23 | EXP |
Vapor Pressure | 0.029 | mm Hg | 25 | EST |
Henry's Law Constant | 9.91E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.56E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.