Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: N-Nitroso-N-methylurea
RN: 684-93-5
UNII: W8KW4E3XSU
InChIKey: ZRKWMRDKSOPRRS-UHFFFAOYSA-N

Note

  • A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.

Molecular Formula

  • C2-H5-N3-O2

Molecular Weight

  • 103.0805
 

Classification Codes

Classification Codes

  • Alkylating Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 1 lb
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Methylnitrosourea
  • N-Nitroso-N-methylurea

MeSH Heading

  • Methylnitrosourea

Synonyms

  • 1-Methyl-1-nitrosomocovina
  • 1-Methyl-1-nitrosomocovina [Czech]
  • 1-Methyl-1-nitrosourea
  • 1-Nitroso-1-methylurea
  • AI3-50583
  • Carbamide, N-methyl-N-nitroso-
  • CCRIS 404
  • EINECS 211-678-4
  • HSDB 5112
  • Methylnitroso-harnstoff
  • Methylnitroso-harnstoff [German]
  • Methylnitrosouree
  • Methylnitrosouree [French]
  • MNU
  • N-Methyl-N-nitroso-harnstoff
  • N-Methyl-N-nitroso-harnstoff [German]
  • N-Methyl-N-nitrosourea
  • N-Nitroso-N-methyl-harnstoff
  • N-Nitroso-N-methyl-harnstoff [German]
  • N-Nitroso-N-methylcarbamide
  • N-Nitroso-N-methylurea
  • Nitrosomethylurea
  • NMH
  • NMH [German]
  • NMU
  • NSC 23909
  • NSC-23909
  • O-Nitroso-N-methyl-harnstoff
  • O-Nitroso-N-methyl-harnstoff [German]
  • RCRA waste number U177
  • SKI 24464
  • SRI 859
  • UNII-W8KW4E3XSU

Systematic Names

  • 1-Methyl-1-nitrosourea
  • N-Methyl-N-nitrosourea
  • Urea, 1-methyl-1-nitroso- (8CI)
  • Urea, N-methyl-N-nitroso-

Superlist Names

  • N-Methyl-N-nitrosourea
  • N-Nitroso-N-methylurea
  • RCRA waste no. U177
  • Urea, N-methyl-N-nitroso-

Registry Numbers

CAS Registry Number

  • 684-93-5

FDA UNII

  • W8KW4E3XSU

Other Registry Numbers

  • 126742-50-5
  • 820-60-0

System Generated Number

  • 0000684935

Structure Descriptors

InChI

InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

InChIKey

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

Smiles

CN(N=O)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 subcutaneous 113mg/kg (113mg/kg)   British Journal of Cancer. Vol. 29, Pg. 359, 1974.
hamster LDLo intravenous 42mg/kg (42mg/kg)   Journal of Pathology and Bacteriology. Vol. 92, Pg. 35, 1966.
mammal (species unspecified) LD50 intravenous 110mg/kg (110mg/kg)   Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975.
mammal (species unspecified) LD50 oral 110mg/kg (110mg/kg)   Gann Monograph on Cancer Research. Vol. 17, Pg. 107, 1975.
mouse LD50 intraperitoneal 144mg/kg (144mg/kg)   Cancer Research. Vol. 30, Pg. 11, 1970.
rat LD50 intraperitoneal 110mg/kg (110mg/kg)   Nature. Vol. 222, Pg. 1064, 1969.
rat LD50 intravenous 108mg/kg (108mg/kg)   Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. Vol. 257, Pg. 296, 1967.
rat LD50 oral 110mg/kg (110mg/kg)   Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
rat LDLo implant 30mg/kg (30mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Chemico-Biological Interactions. Vol. 5, Pg. 139, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 123.5 dec deg C   EXP
log P (octanol-water) -0.03 (none)   EXP
Water Solubility 1.44E+04 mg/L 23 EXP
Vapor Pressure 0.029 mm Hg 25 EST
Henry's Law Constant 9.91E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.56E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.