Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Ceftizoxime sodium [USAN:USP:JAN]
RN: 68401-82-1
UNII: 26337D5X88
InChIKey: ADLFUPFRVXCDMO-LIGXYSTNSA-M

Note

  • A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.

Molecular Formula

  • C13-H12-N5-O5-S2.Na

Molecular Weight

  • 405.3898
 

Classification Codes

  • Antibacterial
  • Antibiotics
  • Drug / Therapeutic Agent
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Ceftizoxime sodium [USAN:USP:JAN]

MeSH Heading

  • Ceftizoxime

Synonyms

  • Cefizox
  • Cefizox in dextrose 5% in plastic container
  • Cefizox in plastic container
  • Ceftizoxim-natrium
  • Ceftizoxim-natrium [German]
  • Ceftizoxime sodium
  • Epocelin
  • Eposerin
  • FK 749
  • FR 13749
  • FX 749
  • SK&F 88373-Z
  • SKF 88373-Z
  • Sodium (6R,7R)-7-(2-(2-imino-4-thiazolin-4-yl)glyoxylamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate 7(sup 2)-(Z)-(O-methyloxime)
  • UNII-26337D5X88

Systematic Names

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2,3-dihydro-2-imino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxomonosodium salt, (6R-(6alpha,7beta(Z)))-
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)-(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6-alpha,7-beta(Z)))-

Registry Numbers

CAS Registry Number

  • 68401-82-1

FDA UNII

  • 26337D5X88

Related Registry Number

  • 68401-81-0 (Parent)

System Generated Number

  • 0068401821

Molecular Formulas

Molecular Formula

  • C13-H12-N5-O5-S2.Na

Molecular Formula Fragments

  • C13-H12-N5-O5-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1

InChIKey

ADLFUPFRVXCDMO-LIGXYSTNSA-M

Smiles

CO/N=C(/c1csc(n1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=CCS3)C(=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous > 3200mg/kg (3200mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
mouse LD50 intraperitoneal 8930mg/kg (8930mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
mouse LD50 intravenous 5150mg/kg (5150mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 905, 1982.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rabbit LDLo intravenous > 3200mg/kg (3200mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rabbit LDLo oral > 3200mg/kg (3200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat LD50 intraperitoneal 8130mg/kg (8130mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat LD50 intravenous 5570mg/kg (5570mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat LD50 oral > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1669, 1980.