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Substance Name: Anagrelide [INN:BAN]
RN: 68475-42-3
UNII: K9X45X0051
InChIKey: OTBXOEAOVRKTNQ-UHFFFAOYSA-N

Note

  • Imidazoquinazoline derivative which lowers platelet count probably by inhibiting thrombopoiesis and reduces platelet aggregation; used for thrombocythemia.

Molecular Formula

  • C10-H7-Cl2-N3-O

Molecular Weight

  • 256.091
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Human Data
  • Platelet Aggregation Inhibitors

Names and Synonyms

Name of Substance

  • Anagrelide [INN:BAN]

Synonyms

  • 6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on
  • 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one
  • Anagrelida
  • Anagrelida [INN-Spanish]
  • Anagrelide
  • Anagrelidum
  • Anagrelidum [INN-Latin]
  • BL 416201
  • BRN 0619582
  • HSDB 7325
  • UNII-K9X45X0051
  • Xagrid

Systematic Name

  • Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-

Registry Numbers

CAS Registry Number

  • 68475-42-3

FDA UNII

  • K9X45X0051

System Generated Number

  • 0068475423

Structure Descriptors

InChI

1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)

InChIKey

OTBXOEAOVRKTNQ-UHFFFAOYSA-N

Smiles

c1(c(c2c(N=C3N(C2)CC(N3)=O)cc1)Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo unreported 300ug/kg/7D (0.3mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: HEADACHE
Proceedings of the American Association for Cancer Research. Vol. 29, Pg. 212, 1988.