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Substance Name: Anagrelide [INN:BAN]
RN: 68475-42-3
UNII: K9X45X0051
InChIKey: OTBXOEAOVRKTNQ-UHFFFAOYSA-N
Note
- Imidazoquinazoline derivative which lowers platelet count probably by inhibiting thrombopoiesis and reduces platelet aggregation; used for thrombocythemia.
Molecular Formula
- C10-H7-Cl2-N3-O
Molecular Weight
- 256.091
Classification Codes
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Fibrin Modulating Agents
- Fibrinolytic Agents
- Hematologic Agents
- Human Data
- Platelet Aggregation Inhibitors
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Names and Synonyms
Name of Substance
- Anagrelide [INN:BAN]
Synonyms
- 6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on
- 6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one
- Anagrelida
- Anagrelida [INN-Spanish]
- Anagrelide
- Anagrelidum
- Anagrelidum [INN-Latin]
- BL 416201
- BRN 0619582
- HSDB 7325
- UNII-K9X45X0051
- Xagrid
Systematic Name
- Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-
Registry Numbers
CAS Registry Number
- 68475-42-3
FDA UNII
- K9X45X0051
System Generated Number
- 0068475423
Structure Descriptors
InChI
1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)InChIKey
OTBXOEAOVRKTNQ-UHFFFAOYSA-NSmiles
c1(c(c2c(N=C3N(C2)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | unreported | 300ug/kg/7D (0.3mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: HEADACHE | Proceedings of the American Association for Cancer Research. Vol. 29, Pg. 212, 1988. |