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Substance Name: Apyramide
RN: 68483-33-0
UNII: 89832816U3
InChIKey: KWUFTKVMXUYTBF-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C27-H23-Cl-N2-O5

Molecular Weight

  • 490.9407
 
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Names and Synonyms

Name of Substance

  • Apyramide

Synonyms

  • (p-Chlorobenzoyl-1 methyl-2 methoxy-5)-indole-3 acetate de p-acetamidophenol
  • (p-Chlorobenzoyl-1 methyl-2 methoxy-5)-indole-3 acetate de p-acetamidophenol [French]
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(acetylamino)phenyl ester
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-p-acetamidophenol acetate
  • Apyramide
  • EINECS 270-913-9
  • UNII-89832816U3

Systematic Names

  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(acetylamino)phenyl ester
  • 4-(Acetylamino)phenyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

Registry Numbers

CAS Registry Number

  • 68483-33-0

FDA UNII

  • 89832816U3

System Generated Number

  • 0068483330

Structure Descriptors

InChI

1S/C27H23ClN2O5/c1-16-23(15-26(32)35-21-10-8-20(9-11-21)29-17(2)31)24-14-22(34-3)12-13-25(24)30(16)27(33)18-4-6-19(28)7-5-18/h4-14H,15H2,1-3H3,(H,29,31)

InChIKey

KWUFTKVMXUYTBF-UHFFFAOYSA-N

Smiles

Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)Oc4ccc(cc4)NC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 81600ug/kg (81.6mg/kg)   Drugs under Experimental and Clinical Research. Vol. 13, Pg. 247, 1987.
mouse LD50 oral 380mg/kg (380mg/kg)   Drugs of the Future. Vol. 12, Pg. 203, 1987.
mouse LD50 unreported 4gm/kg (4000mg/kg)   French Demande Patent Document. Vol. #2358145,
rat LD50 intraperitoneal 200mg/kg (200mg/kg)   Drugs under Experimental and Clinical Research. Vol. 13, Pg. 247, 1987.
rat LD50 oral 887mg/kg (887mg/kg)   Drugs under Experimental and Clinical Research. Vol. 13, Pg. 247, 1987.