Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Mecasermin [USAN:INN:BAN]
RN: 68562-41-4
UNII: 7GR9I2683O
InChIKey: LAMDNSOIUVRQNV-CERJTIPZSA-N

Note

  • A 12 kDa protein consists of 117 amino acids; may play a role in the differentiation of cerebellar neurons, particularly the granule cells; associated with cardiac hypertrophy; RefSeq NM_024374 (rat); NM_008098 (mouse); NM_145808 (human).

Molecular Formula

  • C331-H512-N94-O101-S7

Molecular Weight

  • 7648.7048
 

Classification Codes

  • Drug / Therapeutic Agent
  • Growth Substances
  • Reproductive Effect
  • Treatment of Amyotrophic Lateral Sclerosis
  • Treatment of Diabetes Mellitus (Types I and II)
  • Treatment of Growth Hormone Insensitivity (GHIS)
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Mecasermin [USAN:INN:BAN]

Synonyms

  • CCRIS 6804
  • CEP 151
  • CEP-151
  • Human somatomedin C
  • Increlex
  • Insulin-like growth factor-I (human)
  • Mecasermin
  • Myotrophin
  • rhIGF-1
  • Somazon
  • UNII-7GR9I2683O

Systematic Names

  • Insulin-like growth factor I (human)
  • Somazon

Registry Numbers

CAS Registry Number

  • 68562-41-4

FDA UNII

  • 7GR9I2683O

System Generated Number

  • 0068562414

Structure Descriptors

InChI

1S/C331H512N94O101S7/c1-31-168(20)259-319(519)417-258(167(18)19)317(517)403-221(140-255(461)462)296(496)383-199(99-105-250(451)452)279(479)409-232-158-533-532-156-230-307(507)399-220(139-254(459)460)297(497)392-206(125-161(6)7)285(485)378-191(74-52-113-353-328(343)344)271(471)377-193(76-54-115-355-330(347)348)273(473)390-205(124-160(4)5)286(486)382-198(98-104-249(449)450)276(476)384-201(107-122-527-30)280(480)393-215(135-184-87-93-187(436)94-88-184)293(493)410-229(305(505)367-173(25)322(522)423-119-58-81-236(423)312(512)400-207(126-162(8)9)287(487)387-202(70-45-48-109-333)323(523)424-120-59-79-234(424)309(509)365-171(23)264(464)373-189(69-44-47-108-332)274(474)404-223(149-427)300(500)368-174(26)325(525)526)155-530-529-154-228(413-318(518)257(166(16)17)416-299(499)216(132-181-67-42-35-43-68-181)394-277(477)195(95-101-238(336)437)381-284(484)204(123-159(2)3)389-265(465)170(22)364-283(483)219(138-253(457)458)402-316(516)256(165(14)15)415-298(498)209(128-164(12)13)391-278(478)197(97-103-248(447)448)374-263(463)169(21)363-241(440)142-359-268(468)227(408-288(488)208(127-163(10)11)401-320(520)262(177(29)433)419-282(482)200(100-106-251(453)454)386-310(510)233-78-56-117-421(233)247(446)141-335)153-528-531-157-231(412-308(232)508)306(506)397-212(130-179-63-38-33-39-64-179)290(490)379-194(77-55-116-356-331(349)350)275(475)405-226(152-430)304(504)411-230)269(469)360-144-243(442)371-218(137-252(455)456)295(495)375-188(72-50-111-351-326(339)340)266(466)357-143-242(441)370-211(129-178-61-36-32-37-62-178)289(489)395-214(134-183-85-91-186(435)92-86-183)291(491)396-213(131-180-65-40-34-41-66-180)292(492)398-217(136-240(338)439)294(494)388-203(71-46-49-110-334)324(524)425-121-60-82-237(425)313(513)420-261(176(28)432)315(515)361-146-244(443)369-210(133-182-83-89-185(434)90-84-182)267(467)358-145-245(444)372-222(148-426)301(501)406-225(151-429)303(503)407-224(150-428)302(502)380-192(75-53-114-354-329(345)346)272(472)376-190(73-51-112-352-327(341)342)270(470)366-172(24)321(521)422-118-57-80-235(422)311(511)385-196(96-102-239(337)438)281(481)418-260(175(27)431)314(514)362-147-246(445)414-259/h32-43,61-68,83-94,159-177,188-237,256-262,426-436H,31,44-60,69-82,95-158,332-335H2,1-30H3,(H2,336,437)(H2,337,438)(H2,338,439)(H,357,466)(H,358,467)(H,359,468)(H,360,469)(H,361,515)(H,362,514)(H,363,440)(H,364,483)(H,365,509)(H,366,470)(H,367,505)(H,368,500)(H,369,443)(H,370,441)(H,371,442)(H,372,444)(H,373,464)(H,374,463)(H,375,495)(H,376,472)(H,377,471)(H,378,485)(H,379,490)(H,380,502)(H,381,484)(H,382,486)(H,383,496)(H,384,476)(H,385,511)(H,386,510)(H,387,487)(H,388,494)(H,389,465)(H,390,473)(H,391,478)(H,392,497)(H,393,480)(H,394,477)(H,395,489)(H,396,491)(H,397,506)(H,398,492)(H,399,507)(H,400,512)(H,401,520)(H,402,516)(H,403,517)(H,404,474)(H,405,475)(H,406,501)(H,407,503)(H,408,488)(H,409,479)(H,410,493)(H,411,504)(H,412,508)(H,413,518)(H,414,445)(H,415,498)(H,416,499)(H,417,519)(H,418,481)(H,419,482)(H,420,513)(H,447,448)(H,449,450)(H,451,452)(H,453,454)(H,455,456)(H,457,458)(H,459,460)(H,461,462)(H,525,526)(H4,339,340,351)(H4,341,342,352)(H4,343,344,353)(H4,345,346,354)(H4,347,348,355)(H4,349,350,356)/t168-,169-,170-,171-,172-,173-,174-,175+,176+,177+,188-,189-,190-,191-,192-,193-,194-,195-,196-,197-,198-,199-,200-,201-,202-,203-,204-,205-,206-,207-,208-,209-,210-,211-,212-,213-,214-,215-,216-,217-,218-,219-,220-,221-,222-,223-,224-,225-,226-,227-,228-,229-,230-,231-,232-,233-,234-,235-,236-,237-,256-,257-,258-,259-,260-,261-,262-/m0/s1

InChIKey

LAMDNSOIUVRQNV-CERJTIPZSA-N

Smiles

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)[C@@H](C)O)CCC(=O)N)C)CCCNC(=N)N)CCCNC(=N)N)CO)CO)CO)Cc6ccc(cc6)O)[C@@H](C)O)CCCCN)CC(=O)N)Cc7ccccc7)Cc8ccc(cc8)O)Cc9ccccc9)CCCNC(=N)N)CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3)CO)CCCNC(=N)N)Cc1ccccc1)NC2=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CN)C)CCC(=O)O)CC(C)C)C(C)C)CC(=O)O)C)CC(C)C)CCC(=O)N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O)Cc1ccc(cc1)O)CCSC)CCC(=O)O)CC(C)C)CCCNC(=N)N)CCCNC(=N)N)CC(C)C)CC(=O)O)CCC(=O)O)CC(=O)O)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo intravenous 3200ug/kg (3.2mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 710, 1995.
monkey LDLo subcutaneous 3200ug/kg (3.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 710, 1995.
rat LDLo subcutaneous 32mg/kg (32mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 27, Pg. 710, 1995.