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Substance Name: (-)-Tylocrebrine
RN: 6879-02-3
UNII: 3807I5NR9S
InChIKey: YFEPHJVWLFGWKH-CQSZACIVSA-N

Note

  • An indolizidine; isomer of APORPHINES.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H27-N-O4

Molecular Weight

  • 393.4803
 
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Names and Synonyms

Results Name

  • (-)-Tylocrebrine

Name of Substance

  • Tylocrebrine

Synonyms

  • (-)-Tylocrebrine
  • BRN 1555044
  • Dibenzo(f,h)pyrrolo(1,2-b)isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-
  • Lylocrebrine
  • NSC-60387
  • Tylocerebrine
  • Tylocrebine
  • Tylocrebrin
  • UNII-3807I5NR9S

Systematic Names

  • Dibenzo(f,h)pyrrolo(1,2-b)isoquinoline, 9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-, (R)- (9CI)
  • Tylocrebrine

Registry Numbers

CAS Registry Number

  • 6879-02-3

FDA UNII

  • 3807I5NR9S

System Generated Number

  • 0006879023

Structure Descriptors

InChI

1S/C24H27NO4/c1-26-20-8-7-15-19-13-25-9-5-6-14(25)10-16(19)17-11-21(27-2)22(28-3)12-18(17)23(15)24(20)29-4/h7-8,11-12,14H,5-6,9-10,13H2,1-4H3/t14-/m1/s1

InChIKey

YFEPHJVWLFGWKH-CQSZACIVSA-N

Smiles

COc1ccc2c3c(c4cc(c(cc4c2c1OC)OC)OC)C[C@H]5CCCN5C3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 42mg/kg (42mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co.Vol. -, Pg. 77, 1964.
mouse LD50 oral 50mg/kg (50mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co.Vol. -, Pg. 77, 1964.
rat LD50 intravenous 32mg/kg (32mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co.Vol. -, Pg. 77, 1964.
rat LD50 oral 65mg/kg (65mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co.Vol. -, Pg. 77, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 220 deg C   EXP
log P (octanol-water) 4.400 (none)   EST
Atmospheric OH Rate Constant 2.45E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.