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Substance Name: Licorice extract
RN: 68916-91-6

Note

  • Tinctures, concretes, absolutes, essential oils, oleoresine, terpenes. terpene-free fractions, distillates, residues obtained from Glycyrrhiza glara, Leguminosae

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
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Links to Resources

Names and Synonyms

Name of Substance

  • Licorice extract

Synonyms

  • EINECS 272-837-1
  • FEMA No. 2628
  • FEMA No. 2629
  • FEMA No. 2630
  • Gan Cao
  • Glycyrrhiza extract
  • Glycyrrhizae
  • Glycyrrhizae [Latin]
  • HSDB 1925
  • Kanzo
  • Kanzo [Japanese]
  • Kanzou
  • Kanzou [Chinese]
  • Licorice extract
  • Licorice extract (Glycyrrhiza spp.)
  • Licorice extract powder (Glycyrrhiza glabra L.)
  • Licorice root (Glycyrrhiza glabra L.)
  • Licorice root extract
  • Zhi Gan Cao

Systematic Names

  • Glycyrrhiza extract
  • Licorice, ext.

Superlist Name

  • Licorice extract

Registry Numbers

CAS Registry Number

  • 68916-91-6

Other Registry Numbers

  • 8008-94-4
  • 8057-63-4
  • 85085-44-5

System Generated Number

  • 0068916916

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 209gm/kg/2Y-I (209000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Italian Journal of Neurological Sciences. Vol. 4, Pg. 493, 1983.
mouse LD50 intraperitoneal 1500mg/kg (1500mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
mouse LD50 oral > 7500mg/kg (7500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
mouse LD50 subcutaneous 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: CHANGES IN SPLEEN
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
rat LD50 intraperitoneal 1420mg/kg (1420mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
rat LD50 oral 14200mg/kg (14200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.
rat LD50 subcutaneous 4200mg/kg (4200mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 535, 1977.