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Substance Name: Liothyronine [INN:BAN]
RN: 6893-02-3
UNII: 06LU7C9H1V
InChIKey: AUYYCJSJGJYCDS-LBPRGKRZSA-N

Note

  • A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

Molecular Formula

  • C15-H12-I3-N-O4

Molecular Weight

  • 650.963
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Liothyronine
  • Liothyronine [INN:BAN]
  • Triiodothyronine

MeSH Heading

  • Triiodothyronine

Synonyms

  • 3,3',5-Triiodo-L-thyronine
  • 3,3',5-Triiodothyronine
  • 3,3',5-Triiodothyronine, L-
  • 3,5,3'-Tri-iodo-L-thyronine
  • 3,5,3'-Triiodothyronine
  • 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine
  • 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine
  • 4-14-00-02373 (Beilstein Handbook Reference)
  • Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L-
  • BRN 2710227
  • EINECS 229-999-3
  • HSDB 3110
  • L-3,3',5-TriioDOThyronine
  • L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine
  • L-Liothyronine
  • L-T3
  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
  • Liothyronin
  • Liothyronine
  • Liothyroninum
  • Liothyroninum [INN-Latin]
  • Liotironina
  • Liotironina [INN-Spanish]
  • Lyothyronine
  • NSC 80203
  • O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
  • T3
  • T3 (amino acid)
  • T3 (Hormone)
  • T3 (VAN)
  • Thyronine, 3,3',5-triiodo-, L- (6CI)
  • Tresitope
  • Triiodo-L-thyronine
  • Triiodothyronine
  • Triiodothyronine, l-
  • Triothyrone
  • UNII-06LU7C9H1V

Systematic Names

  • Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L-
  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- (9CI)
  • Liothyronine

Mixture Name

  • Armour Thyroid

Registry Numbers

CAS Registry Number

  • 6893-02-3

FDA UNII

  • 06LU7C9H1V

Other Registry Numbers

  • 57164-27-9
  • 7013-53-8

System Generated Number

  • 0006893023

Structure Descriptors

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChIKey

AUYYCJSJGJYCDS-LBPRGKRZSA-N

Smiles

c1(Oc2cc(c(O)cc2)I)c(cc(C[C@@H](C(O)=O)N)cc1I)I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LDLo oral 7500mg/kg (7500mg/kg)   Roczniki Panstwowego Zakladu Higieny. Vol. 32, Pg. 197, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 236.5 dec deg C   EXP
log P (octanol-water) 2.960 (none)   EST
Water Solubility 3.96 mg/L 37 EXP
Vapor Pressure 3.90E-16 mm Hg 25 EST
Henry's Law Constant 3.41E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.82E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.