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Substance Name: Chlorpromazine hydrochloride [USP:BAN:JAN]
RN: 69-09-0
UNII: 9WP59609J6
InChIKey: FBSMERQALIEGJT-UHFFFAOYSA-N
Note
- The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Molecular Formula
- C17-H19-Cl-N2-S.Cl-H
Molecular Weight
- 355.331
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Emetic
- Antipsychotic
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Chlorpromazine hydrochloride [USP:BAN:JAN]
Synonyms
- 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride
- 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine monohydrochloride
- AI3-28023
- Aminazin monohydrochloride
- Aminazinum
- Ampliactil monohydrochloride
- CCRIS 6221
- Chloractil
- Chlorazin
- Chloropromazine monohydrochloride
- Chlorpromazine HCl
- Chlorpromazine hydrochloride
- Chlorpromazine hydrochloride intensol
- Chlorpromazine monohydrochloride
- Chlorpromazinium chloride
- Contomin hydrochloride
- CPZ (VAN)
- EINECS 200-701-3
- Fenactil monohydrochloride
- Hebanil
- Hibernal
- Hybernal
- Klorproman
- Klorpromex
- Largactil monohydrochloride
- Lomazine
- Marazine
- Megaphen hydrochloride
- Megatil
- NCI-C05210
- Neurazine
- Norcozine
- NSC 17479
- Plegomazin
- Promachel
- Promacid
- Promapar
- Promexin
- Propaphenin
- Sonazine
- Taroctyl
- Thorazine
- Tranzine
- UNII-9WP59609J6
- Unitensen
Systematic Names
- 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, hydrochloride (1:1)
- 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride
- Chlorpromazine hydrochloride
- Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, monohydrochloride
Registry Numbers
CAS Registry Number
- 69-09-0
FDA UNII
- 9WP59609J6
System Generated Number
- 0000069090
Molecular Formulas
Molecular Formula
- C17-H19-Cl-N2-S.Cl-H
Molecular Formula Fragments
- C17-H19-Cl-N2-S
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1HInChIKey
FBSMERQALIEGJT-UHFFFAOYSA-NSmiles
Cl.CN(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LD50 | intraperitoneal | 160mg/kg (160mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960. | |
chicken | LD50 | intravenous | 28mg/kg (28mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960. | |
guinea pig | LD50 | intraperitoneal | 109mg/kg (109mg/kg) | Pharmazie. Vol. 38, Pg. 749, 1983. | |
guinea pig | LD50 | subcutaneous | 420mg/kg (420mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962. | |
man | TDLo | intravenous | 1786ug/kg/2D- (1.786mg/kg) | BEHAVIORAL: IRRITABILITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Biological Psychiatry. Vol. 18, Pg. 1441, 1983. |
man | TDLo | oral | 6071ug/kg (6.071mg/kg) | Israel Journal of Medical Sciences. Vol. 5, Pg. 1254, 1969. | |
man | TDLo | oral | 18mg/kg (18mg/kg) | Israel Journal of Medical Sciences. Vol. 5, Pg. 1254, 1969. | |
monkey | LDLo | oral | > 30mg/kg (30mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: REGIDITY | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 129, 1959. |
mouse | LC50 | inhalation | 40mg/m3/2H (40mg/m3) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1106, 1986. | |
mouse | LD50 | intraperitoneal | 92200ug/kg (92.2mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 558, 1960. | |
mouse | LD50 | intravenous | 20mg/kg (20mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 808, 1971. | |
mouse | LD50 | oral | 135mg/kg (135mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING | Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 1179, 1976. |
mouse | LD50 | subcutaneous | 420mg/kg (420mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 22, Pg. 301, 1964. | |
rabbit | LD50 | intravenous | 5mg/kg (5mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 15, 1972. | |
rat | LC50 | inhalation | 40mg/m3/2H (40mg/m3) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1106, 1986. | |
rat | LD50 | intraperitoneal | 62mg/kg (62mg/kg) | Psychopharmacologia Vol. 12, Pg. 142, 1968. | |
rat | LD50 | intravenous | 25mg/kg (25mg/kg) | Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 5, Pg. 269, 1963. | |
rat | LD50 | oral | 145mg/kg (145mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 148, Pg. 151, 1965. | |
rat | LD50 | unreported | 90mg/kg (90mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 15, 1972. | |
women | TDLo | intravenous | 822ug/kg (0.822mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Annals of Emergency Medicine. Vol. 17, Pg. 380, 1988. |
women | TDLo | oral | 6mg/kg (6mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: OTHER CHANGES | Postgraduate Medical Journal. Vol. 60, Pg. 564, 1984. |
women | TDLo | oral | 35gm/kg/16Y-I (35000mg/kg) | BEHAVIORAL: REGIDITY CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Biological Psychiatry. Vol. 18, Pg. 1441, 1983. |