|
|
Substance Name: Fluphenazine [INN:BAN]
RN: 69-23-8
UNII: S79426A41Z
InChIKey: PLDUPXSUYLZYBN-UHFFFAOYSA-N
Note
- A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
Molecular Formula
- C22-H26-F3-N3-O-S
Molecular Weight
- 437.5274
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Drug / Therapeutic Agent
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizing Agents
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Fluphenazine
- Fluphenazine [INN:BAN]
MeSH Heading
- Fluphenazine
Synonyms
- 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine
- 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-
- 10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
- 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
- 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine
- 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
- 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
- 4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
- Dapotum
- EINECS 200-702-9
- Elinol
- Flufenazina
- Flufenazina [DCIT]
- Fluorfenazine
- Fluorophenazine
- Fluorphenazine
- Fluphenazine
- Fluphenazinum
- Fluphenazinum [INN-Latin]
- Ftorphenazine
- HSDB 3334
- Moditen (Tabl or elixir)
- NSC 62323
- Pacinol
- Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)-
- Phthorphenazine
- S94
- Sevinol
- Siqualine
- Siqualon
- SQ 4918
- Triflumethazine
- UNII-S79426A41Z
- Valamina
- Vespazine
Systematic Names
- 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- (9CI)
- 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-
- Fluphenazine
Registry Numbers
CAS Registry Number
- 69-23-8
FDA UNII
- S79426A41Z
Other Registry Number
- 47646-09-3
System Generated Number
- 0000069238
Structure Descriptors
InChI
InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2InChIKey
PLDUPXSUYLZYBN-UHFFFAOYSA-NSmiles
OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 89mg/kg (89mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 145, Pg. 450, 1963. |
mouse | LD50 | intravenous | 51mg/kg (51mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 540, 1960. | |
mouse | LD50 | oral | 220mg/kg (220mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 540, 1960. | |
rat | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 540, 1960. | |
rat | LD50 | subcutaneous | 640mg/kg (640mg/kg) | BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Medicinal Chemistry: A Series of Monographs. Vol. 4(2), Pg. 199, 1967. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | < 25 | deg C | EXP | |
pKa Dissociation Constant | 7.9 | (none) | EXP | |
log P (octanol-water) | 4.36 | (none) | EXP | |
Water Solubility | 31.1 | mg/L | 37 | EXP |
Vapor Pressure | 1.02E-12 | mm Hg | 25 | EST |
Henry's Law Constant | 6.09E-17 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.84E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.