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Substance Name: Chlorisondamine chloride [INN:BAN]
RN: 69-27-2
UNII: 7B58W7756G


  • A Nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.

Molecular Formula

  • C14-H20-Cl4-N2.2Cl

Molecular Weight

  • 429.044

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Chlorisondamine
  • Chlorisondamine chloride [INN:BAN]

MeSH Heading

  • Chlorisondamine


  • 4,5,6,7-Tetrachlor-2-(2-trimethylammonioethyl)-2-methylisoindolinium chlorid
  • 4,5,6,7-Tetrachloro-2-(2-dimethylaminoethyl)-isoindoline dimethochloride
  • Ammonium, (2-(2-methyl-4,5,6,7-tetrachloroisoindolinyl)ethyl)trimethyl-, dichloride
  • Chlorisondamine
  • Chlorisondamine chloride
  • Chlorisondamine dimethochloride
  • Chlorisondamini chloridum
  • Chlorisondamini chloridum [INN-Latin]
  • Chlorure de chlorisondamine
  • Chlorure de chlorisondamine [INN-French]
  • Cloruro de clorisondamina
  • Cloruro de clorisondamina [INN-Spanish]
  • Ecolid
  • Ecolid chloride
  • Ecolid R
  • Hisindamone A
  • Isoindoline, 2-(2-dimethylaminoethyl)-4,5,6,7-tetrachlorodimetho chloride
  • N-((2-Dimethylammonium)ethyl)-4,5,6,7-tetrachloroisoindolinium dimethochloride
  • SU 3088
  • UNII-7B58W7756G

Systematic Names

  • 1H-Isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride
  • 4,5,6,7-Tetrachloro-2-(2-dimethylaminoethyl)-2-methylisoindolinum chloride methochloride
  • Isoindolinium, 4,5,6,7-tetrachloro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride

Registry Numbers

CAS Registry Number

  • 69-27-2


  • 7B58W7756G

Other Registry Number

  • 303-92-4

Related Registry Numbers

  • 69-27-2 (chloride)
  • 69-27-2 (Parent)

System Generated Number

  • 0000069272

Molecular Formulas

Molecular Formula

  • C14-H20-Cl4-N2.2Cl

Molecular Formula Fragments

  • C14-H20-Cl4-N2
  • Cl

Structure Descriptors








Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 62mg/kg (62mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse LD50 intravenous 28mg/kg (28mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00058,
mouse LD50 oral 380mg/kg (380mg/kg)   Bollettino Chimico Farmaceutico. Vol. 103, Pg. 490, 1964.
mouse LD50 subcutaneous 240mg/kg (240mg/kg)   Farmaco, Edizione Scientifica. Vol. 20, Pg. 482, 1965.
rat LD50 intravenous 28mg/kg (28mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 115, Pg. 172, 1955.
rat LD50 oral 300mg/kg (300mg/kg)   Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. Vol. 10, Pg. 15, 1960.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 261 dec deg C   EXP
log P (octanol-water) -4.480 (none)   EST
Atmospheric OH Rate Constant 3.78E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.