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Substance Name: Prenylamine lactate [JAN]
RN: 69-43-2
UNII: 6J3J6SXI7V
InChIKey: QPOFIDVRLWJICD-UHFFFAOYSA-N

Notes

  • A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
  • Prenylamine compounded with lactic acid.

Molecular Formula

  • C24-H27-N.C3-H6-O3

Molecular Weight

  • 419.562
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Prenylamine lactate
  • Prenylamine lactate [JAN]

Synonyms

  • Agozol
  • Angormin
  • Coredamin
  • Corontin
  • Crepasin
  • EINECS 200-705-5
  • Incoran
  • Irrorin
  • N-(3,3-Diphenylpropyl)-alpha-methylphenethylamine lactate
  • Plactamin
  • Prenylamine lactate
  • Reocorin
  • Roinin
  • Seccidin
  • Sedolatan
  • UNII-6J3J6SXI7V

Systematic Names

  • Phenethylamine, N-(3,3-diphenylpropyl)-alpha-methyl-, lactate
  • Prenylamine lactate

Registry Numbers

CAS Registry Number

  • 69-43-2

FDA UNII

  • 6J3J6SXI7V

System Generated Number

  • 0000069432

Molecular Formulas

Molecular Formula

  • C24-H27-N.C3-H6-O3

Molecular Formula Fragments

  • C24-H27-N
  • C3-H6-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C24H27N.C3H6O3/c1-20(19-21-11-5-2-6-12-21)25-18-17-24(22-13-7-3-8-14-22)23-15-9-4-10-16-23;1-2(4)3(5)6/h2-16,20,24-25H,17-19H2,1H3;2,4H,1H3,(H,5,6)

InChIKey

QPOFIDVRLWJICD-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)CCN[C@@H](Cc1ccccc1)C.C[C@@H](O)C(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 680mg/kg (680mg/kg)   Drugs in Japan Vol. 6, Pg. 716, 1982.
mouse LD50 intraperitoneal 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 2127, 1976.
mouse LD50 oral 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 569, 1960.
rat LD50 intraperitoneal 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 2127, 1976.
rat LD50 oral 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 2127, 1976.