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Substance Name: Mannitol [USP]
RN: 69-65-8
UNII: 3OWL53L36A
InChIKey: FBPFZTCFMRRESA-KVTDHHQDSA-N

Note

  • A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.

Molecular Formula

  • C6-H14-O6

Molecular Weight

  • 182.1706
 

Classification Codes

  • Diagnostic Aid (Renal Function Determination)
  • Diuretic
  • Diuretics
  • Diuretics, Osmotic
  • Drug / Therapeutic Agent
  • Flavoring Agents
  • Food Additives
  • Human Data
  • Mutation Data
  • Natriuretic Agents
  • Sweetening Agents
  • Tumor Data

Names and Synonyms

Name of Substance

  • D-Mannitol
  • Mannitol
  • Mannitol [USP]

MeSH Heading

  • Mannitol

Synonyms

  • 4-01-00-02841 (Beilstein Handbook Reference)
  • Aridol
  • BRN 1721898
  • Bronchitol
  • CCRIS 369
  • Cordycepic acid
  • D-Mannitol
  • Diosmol
  • EINECS 200-711-8
  • HSDB 714
  • Invenex
  • Isotol
  • Maniton-S
  • Manna sugar
  • Mannazucker
  • Mannidex
  • Mannigen
  • Mannistol
  • Mannit
  • Mannite
  • Mannitol
  • Mannitol (VAN)
  • Mannitol 10%
  • Mannitol 10% in plastic container
  • Mannitol 10% w/ dextrose 5% in distilled water
  • Mannitol 15%
  • Mannitol 15% in plastic container
  • Mannitol 15% w/ dextrose 5% in sodium chloride 0.45%
  • Mannitol 20%
  • Mannitol 20% in plastic container
  • Mannitol 25%
  • Mannitol 5%
  • Mannitol 5% in plastic container
  • Mannitol 5% w/ dextrose 5% in sodium chloride 0.12%
  • Mannogem 2080
  • Marine Crystal
  • NCI-C50362
  • NSC 407017
  • Osmitrol
  • Osmitrol 10% in water
  • Osmitrol 10% in water in plastic container
  • Osmitrol 15% in water
  • Osmitrol 15% in water in plastic container
  • Osmitrol 20% in water
  • Osmitrol 20% in water in plastic container
  • Osmitrol 5% in water
  • Osmitrol 5% in water in plastic container
  • Osmofundin
  • Osmosal
  • Resectisol
  • Resectisol in plastic container
  • UNII-3OWL53L36A

Systematic Name

  • D-Mannitol

Superlist Names

  • D-Mannitol
  • Mannitol
  • Mannitol, D-

Mixture Name

  • SDM No. 35

Registry Numbers

CAS Registry Number

  • 69-65-8

FDA UNII

  • 3OWL53L36A

Other Registry Numbers

  • 123897-58-5
  • 75398-80-0
  • 85085-15-0

System Generated Number

  • 0000069658

Structure Descriptors

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChIKey

FBPFZTCFMRRESA-KVTDHHQDSA-N

Smiles

O[C@@H]([C@@H]([C@@H](CO)O)O)[C@@H](CO)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 17143mg/kg/2D (17143mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Archives of Internal Medicine. Vol. 144, Pg. 2053, 1984.
mouse LD50 intraperitoneal 14gm/kg (14000mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 98, 1936.
mouse LD50 intravenous 7470mg/kg (7470mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
mouse LD50 oral 22gm/kg (22000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
FAO Nutrition Meetings Report Series. Vol. 40, Pg. 160, 1967.
rat LD50 intravenous 9690mg/kg (9690mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.
rat LD50 oral 13500mg/kg (13500mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 168 deg C   EXP
pKa Dissociation Constant 13.5 (none) 25 EXP
log P (octanol-water) -3.10E+00 (none)   EXP
Water Solubility 2.16E+05 mg/L 25 EXP
Vapor Pressure 4.92E-09 mm Hg 25 EST
Henry's Law Constant 7.26E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.00E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.