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Substance Name: Salicylic acid [USP:JAN]
RN: 69-72-7
UNII: O414PZ4LPZ
InChIKey: YGSDEFSMJLZEOE-UHFFFAOYSA-N
Note
- A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
Molecular Formula
- C7-H6-O3
Molecular Weight
- 138.1214
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Antifungal Agents
- Dermatologic Agents
- Drug / Therapeutic Agent
- Human Data
- Keratolytic
- Keratolytic Agents
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
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Names and Synonyms
Name of Substance
- 2-Hydroxybenzoic acid
- Benzoic acid, 2-hydroxy-
- o-Hydroxybenzoic acid
- Salicylic acid [USP:JAN]
MeSH Heading
- Salicylic acid
Synonyms
- 2-Carboxyphenol
- 2-Hydroxybenzenecarboxylic acid
- 2-Hydroxybenzoic acid
- 4-10-00-00125 (Beilstein Handbook Reference)
- Acido o-idrossibenzoico
- Acido o-idrossibenzoico [Italian]
- Acido salicilico
- Acido salicilico [Italian]
- Acidum salicylicum
- Advanced Pain Relief Callus Removers
- Advanced Pain Relief Corn Removers
- AI3-02407
- Akurza Cream
- Akurza Lotion
- Benzoic acid, 2-hydroxy-
- BRN 0774890
- Caswell No. 731
- CCRIS 6714
- Clear Away Wart Remover
- Compound W
- DHS Sal Shampoo
- Dr. Scholl's Callus Removers
- Dr. Scholl's Corn Removers
- Dr. Scholl's Wart Remover Kit
- Duofilm Wart Remover
- Duoplant
- DuoPlant Gel
- Durasal
- EC 200-712-3
- EINECS 200-712-3
- EPA Pesticide Chemical Code 076602
- Freezone
- HSDB 672
- Hydrisalic Gel
- Ionil
- Ionil-Plus
- Keralyt
- Kyselina 2-hydroxybenzoova
- Kyselina 2-hydroxybenzoova [Czech]
- Kyselina salicylova
- Kyselina salicylova [Czech]
- Mediplast pads
- NSC 180
- o-Carboxyphenol
- o-Hydroxybenzoic acid
- Orthohydroxybenzoic acid
- P&S Shampoo
- Phenol-2-carboxylic acid
- Propa pH Peel-Off Acne Mask
- Psoriacid-S-stift
- Retarder W
- Rutranex
- Salex Cream
- Salex Lotion
- Salicylate
- Salicylic acid
- Salicylic acid collodion
- Salicylic acid soap
- Salicylic acid, tech.
- salicylicum acidum
- Saligel
- Salonil
- Stri-Dex
- Trans-Ver-Sal
- UNII-O414PZ4LPZ
- Verrugon
Systematic Names
- Benzoic acid, 2-hydroxy-
- Salicylic acid
Superlist Name
- Salicylic acid
Mixture Names
- Domerine
- Duofilm
- Fostex
- Keralyt
- Pernox
- Salicylic acid & sulfur soap
- Sebucare
- Sebulex
Registry Numbers
CAS Registry Number
- 69-72-7
FDA UNII
- O414PZ4LPZ
Other Registry Numbers
- 1186130-36-8
- 7681-06-3
- 8052-31-1
System Generated Number
- 0000069727
Structure Descriptors
InChI
1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)InChIKey
YGSDEFSMJLZEOE-UHFFFAOYSA-NSmiles
c1(c(cccc1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | oral | 400mg/kg (400mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959. | |
| mammal (species unspecified) | LC50 | inhalation | > 300mg/m3 (300mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992. | |
| man | TDLo | skin | 57mg/kg (57mg/kg) | SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR | JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980. |
| mouse | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gendai no Rinsho. Vol. 3, Pg. 675, 1969. |
| mouse | LD50 | intravenous | 184mg/kg (184mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971. |
| mouse | LD50 | oral | 480mg/kg (480mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959. | |
| mouse | LD60 | subcutaneous | 520mg/kg (520mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: CHANGE IN RATE | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930. |
| rabbit | LD50 | oral | 1300mg/kg (1300mg/kg) | Drugs in Japan Vol. 6, Pg. 291, 1982. | |
| rabbit | LD50 | skin | > 10gm/kg (10000mg/kg) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971, | |
| rabbit | LDLo | subcutaneous | 6gm/kg (6000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935. | |
| rat | LC50 | inhalation | > 900mg/m3/1H (900mg/m3) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971, | |
| rat | LD50 | intraperitoneal | 157mg/kg (157mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992. |
| rat | LD50 | oral | 891mg/kg (891mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971, |
| rat | LD50 | skin | > 2gm/kg (2000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER LIVER: OTHER CHANGES | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl, |
| women | TDLo | skin | 111mg/kg/10D- (111mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR | Postgraduate Medical Journal. Vol. 70, Pg. 146, 1994. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 158 | deg C | EXP | |
| pKa Dissociation Constant | 2.97 | (none) | EXP | |
| log P (octanol-water) | 2.26 | (none) | EXP | |
| Water Solubility | 2240 | mg/L | 25 | EXP |
| Vapor Pressure | 8.20E-05 | mm Hg | 25 | EXP |
| Henry's Law Constant | 7.34E-09 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.32E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.