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Substance Name: Salicylic acid [USP:JAN]
RN: 69-72-7
UNII: O414PZ4LPZ
InChIKey: YGSDEFSMJLZEOE-UHFFFAOYSA-N

Note

  • A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.

Molecular Formula

  • C7-H6-O3

Molecular Weight

  • 138.1214
 

Classification Codes

  • Anti-Infective Agents
  • Antifungal Agents
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Keratolytic
  • Keratolytic Agents
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • 2-Hydroxybenzoic acid
  • Benzoic acid, 2-hydroxy-
  • o-Hydroxybenzoic acid
  • Salicylic acid [USP:JAN]

MeSH Heading

  • Salicylic acid

Synonyms

  • 2-Carboxyphenol
  • 2-Hydroxybenzenecarboxylic acid
  • 2-Hydroxybenzoic acid
  • 4-10-00-00125 (Beilstein Handbook Reference)
  • Acido o-idrossibenzoico
  • Acido o-idrossibenzoico [Italian]
  • Acido salicilico
  • Acido salicilico [Italian]
  • Acidum salicylicum
  • Advanced Pain Relief Callus Removers
  • Advanced Pain Relief Corn Removers
  • AI3-02407
  • Akurza Cream
  • Akurza Lotion
  • Benzoic acid, 2-hydroxy-
  • BRN 0774890
  • Caswell No. 731
  • CCRIS 6714
  • Clear Away Wart Remover
  • Compound W
  • DHS Sal Shampoo
  • Dr. Scholl's Callus Removers
  • Dr. Scholl's Corn Removers
  • Dr. Scholl's Wart Remover Kit
  • Duofilm Wart Remover
  • Duoplant
  • DuoPlant Gel
  • Durasal
  • EC 200-712-3
  • EINECS 200-712-3
  • EPA Pesticide Chemical Code 076602
  • Freezone
  • HSDB 672
  • Hydrisalic Gel
  • Ionil
  • Ionil-Plus
  • Keralyt
  • Kyselina 2-hydroxybenzoova
  • Kyselina 2-hydroxybenzoova [Czech]
  • Kyselina salicylova
  • Kyselina salicylova [Czech]
  • Mediplast pads
  • NSC 180
  • o-Carboxyphenol
  • o-Hydroxybenzoic acid
  • Orthohydroxybenzoic acid
  • P&S Shampoo
  • Phenol-2-carboxylic acid
  • Propa pH Peel-Off Acne Mask
  • Psoriacid-S-stift
  • Retarder W
  • Rutranex
  • Salex Cream
  • Salex Lotion
  • Salicylate
  • Salicylic acid
  • Salicylic acid collodion
  • Salicylic acid soap
  • Salicylic acid, tech.
  • salicylicum acidum
  • Saligel
  • Salonil
  • Stri-Dex
  • Trans-Ver-Sal
  • UNII-O414PZ4LPZ
  • Verrugon

Systematic Names

  • Benzoic acid, 2-hydroxy-
  • Salicylic acid

Superlist Name

  • Salicylic acid

Mixture Names

  • Domerine
  • Duofilm
  • Fostex
  • Keralyt
  • Pernox
  • Salicylic acid & sulfur soap
  • Sebucare
  • Sebulex

Registry Numbers

CAS Registry Number

  • 69-72-7

FDA UNII

  • O414PZ4LPZ

Other Registry Numbers

  • 1186130-36-8
  • 7681-06-3
  • 8052-31-1

System Generated Number

  • 0000069727

Structure Descriptors

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChIKey

YGSDEFSMJLZEOE-UHFFFAOYSA-N

Smiles

c1(c(cccc1)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 400mg/kg (400mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.
mammal (species unspecified) LC50 inhalation > 300mg/m3 (300mg/m3)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.
man TDLo skin 57mg/kg (57mg/kg) SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR JAMA, Journal of the American Medical Association. Vol. 244, Pg. 660, 1980.
mouse LD50 intraperitoneal 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gendai no Rinsho. Vol. 3, Pg. 675, 1969.
mouse LD50 intravenous 184mg/kg (184mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971.
mouse LD50 oral 480mg/kg (480mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.
mouse LD60 subcutaneous 520mg/kg (520mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

CARDIAC: CHANGE IN RATE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 38, Pg. 9, 1930.
rabbit LD50 oral 1300mg/kg (1300mg/kg)   Drugs in Japan Vol. 6, Pg. 291, 1982.
rabbit LD50 skin > 10gm/kg (10000mg/kg)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971,
rabbit LDLo subcutaneous 6gm/kg (6000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.
rat LC50 inhalation > 900mg/m3/1H (900mg/m3)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971,
rat LD50 intraperitoneal 157mg/kg (157mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 31, 1992.
rat LD50 oral 891mg/kg (891mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 21-3/1971,
rat LD50 skin > 2gm/kg (2000mg/kg) LIVER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl,
women TDLo skin 111mg/kg/10D- (111mg/kg)   Postgraduate Medical Journal. Vol. 70, Pg. 146, 1994.
women TDLo skin 111mg/kg/10D- (111mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR
Postgraduate Medical Journal. Vol. 70, Pg. 146, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 158 deg C   EXP
pKa Dissociation Constant 2.97 (none)   EXP
log P (octanol-water) 2.26 (none)   EXP
Water Solubility 2240 mg/L 25 EXP
Vapor Pressure 8.20E-05 mm Hg 25 EXP
Henry's Law Constant 7.34E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.32E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.