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Substance Name: Alfentanil hydrochloride [USAN]
RN: 69049-06-5
UNII: 333JTI7A2M
InChIKey: AQORHZJDCHLLJN-UHFFFAOYSA-N

Note

  • A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.

Molecular Formula

  • C21-H32-N6-O3.Cl-H

Molecular Weight

  • 452.9837
 
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Names and Synonyms

Name of Substance

  • Alfentanil hydrochloride
  • Alfentanil hydrochloride [USAN]

Synonyms

  • Alfenta
  • Alfentanil
  • Alfentanil HCl
  • Alfentanil hydrochloride
  • EINECS 273-846-3
  • R 39209
  • Rapifen
  • UNII-333JTI7A2M

Systematic Names

  • N-(1-(2-(4-Ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl)-4-(methoxymethyl)piperidin-4-yl)-N-phenylpropionamide hydrochloride
  • Propanamide, N-(1-(2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl)-4-(methoxymethyl)-4-piperidinyl)-N-phenyl-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 69049-06-5

FDA UNII

  • 333JTI7A2M

Other Registry Number

  • 71124-01-1

System Generated Number

  • 0069049065

Molecular Formulas

Molecular Formula

  • C21-H32-N6-O3.Cl-H

Molecular Formula Fragments

  • C21-H32-N6-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H32N6O3.ClH/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26;/h6-10H,4-5,11-17H2,1-3H3;1H

InChIKey

AQORHZJDCHLLJN-UHFFFAOYSA-N

Smiles

Cl.CCN1N=NN(CCN2CCC(COC)(CC2)N(C(=O)CC)c3ccccc3)C1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 20mg/kg (20mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Drug Development Research. Vol. 1, Pg. 83, 1981.
rat LD50 intravenous 47500ug/kg (47.5mg/kg) BEHAVIORAL: ANALGESIA Drug Development Research. Vol. 1, Pg. 83, 1981.