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Substance Name: Nedocromil [USAN:INN:BAN]
RN: 69049-73-6
UNII: 0B535E0BN0
InChIKey: RQTOOFIXOKYGAN-UHFFFAOYSA-N

Note

  • A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.

Molecular Formula

  • C19-H17-N-O7

Molecular Weight

  • 371.343
 

Classification Codes

  • Anti-Allergic (Prophylactic)
  • Anti-Allergic Agents
  • Anti-Asthmatic Agents
  • Anti-Inflammatory Agents
  • Respiratory System Agents

Names and Synonyms

Name of Substance

  • Nedocromil
  • Nedocromil [USAN:INN:BAN]

MeSH Heading

  • Nedocromil

Synonyms

  • 4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-
  • 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)chinolin-2,8-dicarbonsaeure
  • 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid
  • FPL 59002
  • Nedocromil
  • Nedocromilo
  • Nedocromilo [Spanish]
  • Nedocromilum
  • Nedocromilum [Latin]
  • UNII-0B535E0BN0

Systematic Name

  • 4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-

Registry Numbers

CAS Registry Number

  • 69049-73-6

FDA UNII

  • 0B535E0BN0

Related Registry Numbers

  • 101626-68-0 (calcium salt (1:1))
  • 69049-74-7 (di-hydrochloride salt)

System Generated Number

  • 0069049736

Structure Descriptors

InChI

1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)

InChIKey

RQTOOFIXOKYGAN-UHFFFAOYSA-N

Smiles

c12c(c3c(c(cc(o3)C(O)=O)=O)cc1c(cc(n2CC)C(O)=O)=O)CCC

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 299 dec deg C   EXP
log P (octanol-water) 2.22 (none)   EXP
Water Solubility 145 mg/L 25 EST
Vapor Pressure 5.40E-13 mm Hg 25 EST
Henry's Law Constant 6.83E-20 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.98E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.