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Substance Name: Sapropterin dihydrochloride [USAN]
RN: 69056-38-8
UNII: RG277LF5B3
InChIKey: RKSUYBCOVNCALL-NTVURLEBSA-N

Note

  • Co-factor required for catalytic activity of nitric oxide synthases.

Classification Codes

  • Drug / Therapeutic Agent
  • Treatment of Mild-to-Moderate Phenylketonuria (PKU)

Molecular Formula

  • C9-H15-N5-O3.2Cl-H

Molecular Weight

  • 314.1713
 

Names and Synonyms

Name of Substance

  • Sapropterin dihydrochloride
  • Sapropterin dihydrochloride [USAN]

Synonyms

  • (6beta)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
  • (6R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride
  • (6R)-Tetrahydrobiopterin hydrochloride
  • 6R-BH4
  • BioMarin T 1401
  • Biopten
  • Kuvan
  • Sapropterin dihydrochloride
  • Sapropterin HCl
  • Sapropterin hydrochloride
  • Shiratori SN 0588
  • SUN 0588
  • SUN-0588 (Shiratori)
  • T1401
  • T1401 (BioMarin)
  • UNII-RG277LF5B3

Systematic Name

  • 4(1H)-Pteridinone, 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-, dihydrochloride, (6R-(6R*(1R*,2S*)))-

Registry Numbers

CAS Registry Number

  • 69056-38-8

FDA UNII

  • RG277LF5B3

Other Registry Number

  • 90687-77-7

System Generated Number

  • 0069056388

Molecular Formulas

Molecular Formula

  • C9-H15-N5-O3.2Cl-H

Molecular Formula Fragments

  • C9-H15-N5-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1

InChIKey

RKSUYBCOVNCALL-NTVURLEBSA-N

Smiles

Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)N=C(N)N2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 150mg/kg (150mg/kg)   Yakkyoku. Pharmacy. Vol. 43, Pg. 1191, 1992.
mouse LD50 oral 1gm/kg (1000mg/kg)   Yakkyoku. Pharmacy. Vol. 43, Pg. 1191, 1992.
mouse LD50 subcutaneous 239mg/kg (239mg/kg)   Yakkyoku. Pharmacy. Vol. 43, Pg. 1191, 1992.
rat LD50 intravenous 150mg/kg (150mg/kg)   Yakkyoku. Pharmacy. Vol. 43, Pg. 1191, 1992.
rat LD50 oral 1gm/kg (1000mg/kg)   Yakkyoku. Pharmacy. Vol. 43, Pg. 1191, 1992.
rat LD50 subcutaneous 1084mg/kg (1084mg/kg)   Yakkyoku. Pharmacy. Vol. 43, Pg. 1191, 1992.